Internal Medicine
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Infectious Disease Alert Updates
IL-6 Inhibition and Liver Failure; Can Chopsticks Make You Sick?
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Vitamin C, Thiamine, and Steroids for Septic Shock — Still Unproven
Combination treatment with ascorbic acid (vitamin C), thiamine (vitamin B1), and corticosteroids does not improve clinical outcomes in adults with septic shock.
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Biofilm, Tap Water, and a Nosocomial Mycobacterium abscessus Outbreak — Bring on the Sterile Water
Stopping a nosocomial Mycobacterium abscessus outbreak by eschewing tap water.
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Possible Aerosol Spread of SARS-CoV-2 in an Apartment Building
Although not definitive, evidence is consistent with aerosol spread of SARS-CoV-2 in an apartment building as a result of transport through the drainage system to apartments directly above.
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Four Months of Rifampin Is Just as Effective, Safer, and Less Expensive than Nine Months of Isoniazid for Latent Tuberculosis
A health system cost comparison found that four months of rifampin was safer and less expensive than nine months of isoniazid in high-income countries, medium-income countries, and African countries.
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Antibiotic Use in COVID-19 Patients
Fifty-seven percent of patients with COVID-19 infection treated at 38 hospitals in Michigan received early empiric antibiotics, although only 3.5% of patients had documented community-onset bacterial co-infection.
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Seasonal Coronavirus: A “Common Cold Virus” that May Be Lethal in Severely Immunocompromised Patients
Seasonal coronaviruses, which are a frequent cause of benign upper respiratory tract infections, may be fatal in severely immunocompromised patients.
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Repeat SARS-CoV-2 Infection
Whole genome sequencing confirmed that repeat infection with SARS-CoV-2 is possible, something that has consequences for vaccine use and for public health.
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Considerations and Concerns with Vitamin C in Sepsis and Septic Shock
Sepsis remains a major healthcare problem associated with significant morbidity and mortality. Roles for hydrocortisone, ascorbic acid (vitamin C), and thiamine (HAT therapy) as potential adjuvants remain controversial.
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ORANGES and ACTS Trials: No Mortality Benefit with Ascorbic Acid, Thiamine, and Hydrocortisone in Septic Shock Patients
Two double-blinded, placebo-controlled, randomized trials involving 337 patients (ORANGES, n = 137; ACTS, n = 200) with sepsis and septic shock have shown that administration of ascorbic acid, thiamine, and hydrocortisone did not reduce organ dysfunction or improve overall mortality. However, both trials showed that this combination therapy was effective in reducing the time to achieve shock resolution or shock-free days.