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The relationship between patients' prognosis and age in decisions regarding implantable cardioverter-defibrillator (ICD) therapy in the primary prevention of sudden death in heart failure patients is poorly understood and not addressed in randomized device trials. Thus, Dewland and colleagues created a survey that was sent to 3000 randomly selected primary care physicians and general cardiologists nationwide.
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Heart failure (HF) is associated with a high mortality rate, debilitating symptoms, impaired quality of life, and major financial costs.
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Dabigatran etexilate, a direct thrombin inhibitor, is one of a new class of oral anticoagulants that was recently demonstrated in a Phase 3 trial to be effective for the prevention of stroke or systemic embolism (SSE) in patients with atrial fibrillation (AF).
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Cannabis sativa and indica are fragrant flowering plants native to South Central Asia. Their psychoactive properties have been known and used in some form or another for thousands of years in cultures as diverse as ancient Romania and China.
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CAM use by children with cancer being treated at a hospital in Turkey was common and led to several perceived benefits — such as increased blood values, morale, and general condition — but did not affect overall survival.
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Mouse studies have found that dietary choline is associated with increasing levels of plasma trimethylamine-N-oxide (TMAO) and increasing risk of atherosclerosis — a process that is likely mediated by gut microbiota. Two human clinical trials support these findings. The first demonstrates that phosphatidylcholine (PC) increases plasma levels of TMAO. Following broad-spectrum antibiotic use (and subsequent reduction in gut flora), production of TMAO was reduced after a PC challenge. A large population study demonstrates the connection between TMAO and cardiovascular disease.
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It is estimated that there were approximately 219 million cases of malaria in the world in 2010 and 680,000 or these cases were fatal. The majority of deaths occur in children, most in Africa — with one dying every minute. Fourteen countries are estimated to account for 80% of deaths, with the Democratic Republic of the Congo and Nigeria accounting for 40% of total global malaria deaths.