Internal Medicine
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Pharmacogenetics in Primary Care: An Update
Advancements in the area of personalized medicine and understanding how one’s genetics affect health outcomes is an evolving science. The addition of pharmacogenetic testing to the armamentarium of primary care providers presents an opportunity to improve patient care.
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Infectious Disease Alert Updates
Excess Deaths During COVID-19; Subclinical Influenza Infection in Healthcare Workers; Compression Garments Effective in Reducing Cellulitis
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Neurotropism of COVID-19: What Is New?
SARS-CoV-2 may gain access to the brain via the olfactory epithelium. The olfactory epithelium and bulbs may serve as an entry point for SARS-CoV-2 infection into the central nervous system.
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Does the Addition of IV Metronidazole Improve Outcomes of Severe Clostridioides difficile Infection?
These studies indicate that the addition of intravenously administered metronidazole in the treatment of severe Clostridioides difficile infection is unwarranted.
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Malaria and Anemia — Chemoprophylaxis Helps
For young children in Africa who return home after hospitalization for severe anemia, monthly long-acting malaria prophylaxis can reduce the rates of readmission and death during the three months following hospitalization.
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Candidemia in the United States
Candidemia, a common bloodstream infection in the United States, is associated with high mortality. There is concern about increasing resistance to antifungals.
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Healthcare Workers with Antibody to SARS-CoV-2 Have Strong Protection Against Reinfection
A study of healthcare workers demonstrated that the presence of antibody to SARS-CoV-2 spike protein or to nucleocapsid provides strong protection against infection with this virus for up to six months.
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Early Convalescent Plasma for Treatment of COVID-19 in Elderly Patients with Mild Symptoms
Administration of convalescent plasma obtained from survivors of COVID-19 within 72 hours of onset of mild symptoms in elderly patients with COVID-19 was associated with a significant reduction in the risk of development of severe respiratory disease.
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SARS-CoV-2 Antibodies and Multisystem Inflammatory Syndrome in Children
SARS-CoV-2-related multisystem inflammatory syndrome in children (MIS-C) can be severe and life-threatening. New data suggest that the degree of elevation of spike protein receptor-binding domain antibodies could serve as a diagnostic marker of MIS-C as well as point to potential pathogenic processes.
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Report: Record Year-Over-Year Decline in Cancer Death Rate
Fewer smokers, better detection and treatment methods credited with saving lives.