Internal Medicine
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Long-Term Treatment of Hereditary Amyloid Neuropathy with Patisiran
Hereditary transthyretin-mediated amyloidosis with polyneuropathy is effectively treated by patisiran, a lipid nanoparticle ribonucleic acid interference that binds to transthyretin (TTR) messenger RNA and inhibits TTR production in the liver, resulting in reduction of the serum TTR concentration. Treatment effect has been sustained during a five-year open-label extension study.
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Infectious Disease Alert Updates
Outcome of Coccidioidomycosis in the Pre-Antifungal Era; PET Imaging for Fever of Unknown Origin; High Rates of Thromboembolism in COVID-19
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Clinician Alert: XDR Salmonella Typhi Acquired in the United States
Nine patients in the United States with no travel history had typhoid fever due to extensively drug-resistant Salmonella Typhi.
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Ventricular Assist Device Infections: More Questions Than Answers?
Almost two-fifths of patients with left ventricular assist devices develop associated infections. The optimal appropriate management remains to be determined.
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Oral Moxifloxacin vs. Intravenous Ertapenem Followed by Oral Levofloxacin and Metronidazole for Acute Appendicitis
A randomized controlled clinical trial found that a seven-day course of oral moxifloxacin was not noninferior to two days of intravenous ertapenem followed by five days of levofloxacin and metronidazole in adults with uncomplicated acute appendicitis.
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Unexpected Pediatric Benefits of the COVID-19 Pandemic
Despite the global tragedy of the COVID-19 pandemic, clinical experience suggests that there also have been some favorable indirect effects of pandemic-induced lockdowns on pediatric health. Specifically, there are lower rates of unscheduled primary care visits, emergency department visits, and hospitalizations for medical problems – without an increase in incompletely managed serious diseases.
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Getting to the Super Bowl: Lessons from the NFL on Controlling COVID-19
Aggressive implementation of mitigation procedures with continual evaluations and adjustments allowed the National Football League to complete their season with minimal COVID-19 transmission.
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Virus, Variants, Vaccines
The emergence of SARS-CoV-2 variants may compromise the efficacy of current vaccines.
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Mindfulness in Disadvantaged Populations
Participation in mindfulness-based group therapy shows promise for reducing stress and improving functioning in this pilot study involving 27 socioeconomically disadvantaged African-American women.
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Exercise, Screen Time, and Health During the COVID-19 Pandemic
A Canadian survey capturing one week in the early stages of the COVID- 19 pandemic found that respondents reporting exercising outdoors and decreasing or maintaining screen time were more likely to self-report higher levels of mental and physical health. This association was stronger in women when compared to men.