Internal Medicine Alert
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Pimavanserin Tablets (Nuplazid)
Pimavanserin is indicated for the treatment of hallucination and delusions associated with Parkinson's disease psychosis.
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Fitness and Cognition in the Elderly
Peak levels of cardiorespiratory fitness are positively correlated with enhanced cognitive function among older adults.
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The Efficacy of Spironolactone for the Treatment of Drug-resistant Hypertension
Compared to selected other hypotensive drugs, spironolactone was found to be the most effective drug addition for resistant hypertension when added to previous angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker, calcium channel blocker, and thiazide therapy.
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Welcome Back, Saturated Fat
It has become apparent that clinicians have been giving wrong dietary advice to patients for many decades. The low-fat and non-fat food industry was a mistake.
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Clinical Briefs
In this section: watching carefully for suicide risk; tackling chronic cough; and a new treatment for Peyronie's disease.
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Reslizumab Injection (Cinqair)
Reslizumab is indicated for add-on maintenance treatment of adult patients with severe asthma with eosinophilic phenotype.
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Longer Course Therapy for Lyme Disease Is Not Beneficial
A randomized, placebo-controlled clinical trial from the Netherlands found that longer-term antibiotic therapy for Lyme disease did not improve health-related quality of life compared to a standard course of treatment.
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Predicting Seizure Recurrence with Routine EEG After First Unprovoked Seizure
Using positive likelihood ratios, an adult and child with epileptiform discharges on electroencephalography were estimated to have a 77% and 66% probability, respectively, of recurrent seizures.
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Too Much of a Good Thing
In the United States in 2010 and 2011, an estimated 30% of outpatient oral antibiotic prescriptions may have been inappropriate, a finding that supports the need for establishing a goal for outpatient antibiotic stewardship.
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ECG Review: SVT in a 13-Year-Old Patient
The ECG in the figure below was obtained from an otherwise healthy 13-year-old boy. He was alert and hemodynamically stable at the time this ECG was recorded. How should one interpret this tracing?