Internal Medicine Alert
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Clinical Briefs
In this section: nonsteroidal anti-inflammatory drugs and gastrointestinal bleeding; rheumatoid arthritis; and community-acquired pneumonia.
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Delafloxacin Tablets (Baxdela)
Delafloxacin is indicated for the treatment of acute bacterial skin and skin structure infections caused by susceptible organisms.
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Atypical Transient Symptoms Require Aggressive Investigation for Cause
Atypical transient symptoms, such as partial sensory deficit, dysarthria, vertigo and unsteadiness, unusual visual deficits, and diplopia, usually are not classified as transient ischemic attacks, and they frequently are not investigated in the same fashion.
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Glycemic Measures May Vary Depending on Race
In patients with type 1 diabetes, hemoglobin A1c levels overestimate the mean glucose concentration in black persons compared with white persons, possibly owing to racial differences in the glycation of hemoglobin.
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Long-term Use of Proton Pump Inhibitors and Earlier Death
An observational study of a Veterans Affairs population showed that the use of proton pump inhibitors over a median 5.7-year follow-up period increased the risk of death by 25% compared with the use of histamine 2 blockers or no medication.
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Clinical Briefs
In this section: Use caution with a nocturia treatment; an analysis of a cellulitis remedy; and handling influenza patients.
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Sarilumab Injection (Kevzara)
Sarilumab is indicated for the treatment of adults with moderately to severely active rheumatoid arthritis who have demonstrated an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs.
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Possible Benefit From Pharmaceutical-grade Chondroitin on Knee Osteoarthritis
The authors of a European study found a statistically significant and clinically marginally significant reduction in pain at three and six months in patients taking pharmaceutical-grade chondroitin sulfate for knee osteoarthritis.
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Glucose Self-monitoring May Not Be That Useful
Researchers could not find any statistically significant differences in glycemic control or health-related quality of life between patients who performed glucose self-monitoring compared with those who did not.
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Early Hot Flashes Could Signal Increased Risk for Heart Disease
Women 42-55 years of age who experience hot flashes are more likely to exhibit poor vascular function.