Internal Medicine Alert
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Brigatinib Tablets (Alunbrig)
Brigatinib is indicated for the treatment of patients with anaplastic lymphoma kinase-positive metastatic non-small cell lung cancer who have progressed on or are intolerant to crizotinib.
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Fludrocortisone for Orthostatic Hypotension Associated with Parkinson’s Disease
This double-center, double-blind, randomized, controlled trial compared the efficacy of pyridostigmine bromide vs. fludrocortisone and demonstrated that pyridostigmine bromide was not as effective as fludrocortisone.
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Risk Factors for Hospital Readmissions Ending in Death or Transition to Hospice
In this retrospective cohort study, multiple factors were identified during initial hospitalization, including sepsis and shock, that were associated with a hospital readmission within 30 days resulting in death or transition to hospice.
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Safe Treatment Recommendations for Benzodiazepine Dependence
There are clear, evidence-based treatment withdrawal regimens for benzodiazepine-dependent patients.
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Clinical Briefs
In this section: Addressing postprandial glucose elevations; examining the possible connection between COPD and pulmonary embolisms; and defining healthcare's future reality.
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Dupilumab Injection (Dupixent)
Dupilumab is indicated for the treatment of adults with moderate-to-severe atopic dermatitis (eczema) in whom prescription topical therapies are inadequate or not advisable.
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How Many Sex Partners Is 'Too Many'?
Changing mores regarding sex have direct bearing on patterns of sexual behavior and frequencies of STDs.
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Restricting Fluoroquinolone Use Reduces Clostridium difficile Infection More Than Infection Control Methods
An observational study from England showed that restricting fluoroquinolone use reduced incidence of Clostridium difficile infection more than would be predicted by improved infection control methods alone.
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Bright-light Therapy for Daytime Sleepiness in Parkinson’s Disease Patients
Light therapy has been shown to be beneficial in treating excessive daytime sleepiness in Parkinson’s disease patients and also may improve sleep quality.
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Pregabalin Not Effective for Reducing Pain in Acute or Chronic Sciatica
An Australian study of 207 patients suffering from acute and chronic clinically diagnosed sciatica did not find that treatment with pregabalin for eight weeks reduced pain at eight or 52 weeks.