Internal Medicine Alert
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Clinical Briefs
In this section: comparing GLP-1 agonists; weighing two treatments for extended venous thromboembolism; and considering fracture risks possibly associated with inhaled corticosteroids.
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Ibalizumab-uiyk Injection (Trogarzo)
Ibalizumab-uiyk, in combination with other antiretrovirals, is indicated for the treatment of HIV-1 in heavily treatment-experienced adults with multidrug-resistant HIV infections failing their current regimens.
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After Myocardial Infarction, Increased Risk for Ischemic Stroke Persists for 12 Weeks
This study establishes that the elevated short-term risk of stroke extends beyond 30 days and remains elevated for up to 12 weeks following acute myocardial infarction.
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Stroke Risk in Atrial Fibrillation: A Moving Target?
An investigation of patients in a national database with atrial fibrillation, no comorbidities, and not on aspirin or anticoagulants showed that the clinical features that make up the CHA2DS2-VASc score change over time and can increase a patient’s risk for stroke, which could affect therapy decisions. Thus, the CHA2DS2-VASc score should be reassessed periodically and appropriate therapeutic actions taken promptly.
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Elderly May Not Benefit From Statins for Primary Prevention
In an examination of the data from the much-publicized Systolic Blood Pressure Intervention Trial (SPRINT), the author found no benefit of statin therapy for primary prevention of cardiovascular events or all-cause mortality.
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Clinical Briefs
In this section: improving cardiovascular outcomes in type 2 diabetes patients; digging deeper into penicillin allergies; and treating osteoporosis.
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Apalutamide Tablets (Erleada)
Apalutamide is indicated for the treatment of patients with non-metastatic, castration-resistant prostate cancer.
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Providers Facilitate Transmission of Resistant Organisms
A closer look at the role providers play in the transmission of carbapenem-resistant Enterobacteriaceae.
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Physician Burnout: A Multi-specialty Perspective
Although different specialties address the problem of physician burnout, studies suggest the most effect is gained from organizational interventions.
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Another Reason to Get the Flu Shot Every Year
In a case-control study, among older adults, repeated vaccination for influenza was twice as effective in preventing severe influenza compared to non-severe influenza in patients who were admitted to the hospital.