Internal Medicine Alert
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Combined Treatments with Medications for Hypertension and Hyperlipidemia Dramatically Reduce the Risk of Stroke
In this real-world study, fixed-dose candesartan/hydrochlorothiazide combined with low-dose rosuvastatin reduced first stroke by 44% in patients at intermediate risk of cardiovascular disease and was well tolerated, with minimum dropout of patients.
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Chiropractic Spinal Manipulation for Migraine
Chiropractic spinal manipulation offers no benefit over placebo for migraineurs.
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The Pulmonary Embolism Rule-out Criteria in Low-risk Patients
A cluster randomized trial of the pulmonary embolism rule-out criteria (PERC) compared to usual care for patients estimated to be at low risk of pulmonary embolus (PE) in EDs showed that PERC was non-inferior to usual care at identifying patients who would be free of symptomatic PE at three months, resulting in less use of healthcare resources.
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Fostamatinib Disodium Hexahydrate Tablets (Tavalisse)
Fostamatinib is indicated for the treatment of thrombocytopenia in adults with chronic immune thrombocytopenia with insufficient response to a previous treatment.
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Running and Health
In a review and meta-analysis of the effects of running and longevity, researchers concluded that running provides specific and significant health benefits and proposed a threshold above which more running provides diminishing returns.
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Sleep Habits and the Development of Dementia
The relationship between quality of sleep and the development of dementia is controversial and not yet clearly elucidated nor understood.
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Neurogenesis in Older, Healthy Brains
Healthy aging allows for hippocampal neurogenesis in the brains of adults into the eighth decade of life.
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Coffin Nail for Omega-3 Fatty Acids?
A meta-analysis of 10 randomized, controlled trials of omega-3 fatty acids for the prevention of coronary heart disease and major vascular events showed no significant effect on fatal and nonfatal coronary heart disease or any major vascular event. These results do not support the use of omega-3 fatty acids supplements in patients with prior coronary heart disease.
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Did We Catch Vfib Onset?
Did this patient develop ventricular fibrillation (Vfib) while the ECG in the figure was recorded?
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Efavirenz, Lamivudine, and Tenofovir Disoproxil Fumarate Tablets (Symfi)
Symfi is indicated as a complete regimen for the treatment of HIV-1 infection in adult and pediatric patients weighing at least 40 kg.