Internal Medicine Alert
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Erdafitinib Tablets (Balversa)
Erdafitinib is the first FDA-approved targeted therapy for metastatic bladder cancer.
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The Promise and Perils of the Apple Heart Study
A large study with virtual enrollment of Apple Watch users helped illustrate the positive predictive value of wearable, pulse-based atrial fibrillation detection technology, as well as the ability to enroll and follow huge numbers of research subjects in a short period.
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How Safe Are New Medications for Type 2 Diabetes?
In recent years, new medications have been approved for the management of type 2 diabetes, generally after metformin is given. The FDA has reported 55 cases of Fournier’s gangrene in patients using SGLT2 inhibitors. These medications may not be worth the risk when lifestyle alternatives are available.
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Late Sunsets, Sleep Deprivation, and Adverse Outcomes
All living organisms have 24-hour circadian rhythms. A growing body of evidence shows that chronic disruption of this important rhythm may result in poor health outcomes. These negative consequences of disrupted circadian rhythms might be prevented by modifying work and sleep schedules.
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Hydrogel Capsules (Plenity)
Hydrogel capsules provide a nonsystemic alternative as an aid to weight management.
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The Right Ventricle During Heart Failure With Preserved Left Ventricular Ejection Fraction
A retrospective longitudinal study of heart failure with preserved left ventricular ejection fraction shows that right ventricular function deteriorates more rapidly than left ventricular function and is associated with increased mortality.
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New Insights Into Young Acute Myocardial Infarction Patients
A retrospective contemporary review of STEMI patients younger than 35 years of age shows that these patients are predominantly overweight men who smoke (some abuse drugs and present with dyslipidemia).
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Similar Long-Term Outcomes for Stenting and Endarterectomy for Carotid Stenosis
Researchers conducted a pooled analysis of four large, randomized, controlled trials designed to assess the relative efficacy of carotid artery stenting vs. carotid endarterectomy for treatment of symptomatic carotid artery stenosis.
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Avoid Surprise Migraine Triggers
The degree of unexpectedness or “surprisal” associated with known migraine triggers is a predictor of headache attacks. Social avoidance behavior is positively correlated with headache disability, pain, and depression, but there is a negative correlation between headache pain endurance and anxiety.
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Alcohol Consumption and Migraine
In this observational, cross-sectional survey performed via an online questionnaire, researchers confirmed that alcohol consumption is a common trigger for migraine, and red wine is the type of alcohol cited as a trigger most frequently.