Internal Medicine Alert
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Does Exercise Decrease Incident Depression in a High-Risk Population?
The authors of this large-scale, observational study found that three or more hours weekly of physical activity was associated with a decreased incidence of depression, even in patients with a high genetic risk of depression.
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Lemborexant Tablets (Dayvigo)
Lemborexant should be prescribed to treat adults with insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
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Stable Coronary Disease and Atrial Fibrillation Patients Best Treated With Rivaroxaban Alone
Monotherapy with rivaroxaban was noninferior to combination therapy for the primary efficacy endpoint of composite of stroke, systemic embolism, myocardial infarction, unstable angina, or death from any cause.
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What Is the Optimal Blood Pressure for Secondary Prevention of Stroke?
Investigators terminated a study early before they could draw any firm conclusions. Thus, there remains a lack of solid evidence to support a firm recommendation regarding optimal blood pressure management for secondary stroke prevention.
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Dapagliflozin Treatment Improves Life Quality for Systolic Heart Failure Patients
Treatment with dapagliflozin for 12 weeks resulted in improved health status, either a reduction in NT-proBNP or improvement in quality of life measures, in systolic heart failure patients with or without type 2 diabetes mellitus.
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Menopausal Hormonal Therapy and Breast Cancer Risk: Are Old Data Relevant to Today’s Practice?
An individual-participant meta-analysis of prospective studies revealed menopausal hormone therapy associated with an elevation in the risk of breast cancer, with the highest risks associated with daily combined therapy.
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Can You Interpret This Rhythm?
The long lead II rhythm strip in the figure was obtained from a middle-aged woman with syncope and hypotension. What can you say about the rhythm?
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Minocycline Topical Foam (Amzeeq)
Minocycline topical foam is indicated to treat inflammatory lesions of non-nodular moderate-to-severe acne vulgaris in patients ≥ 9 years of age.
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Anticoagulation Decisions in Atrial Fibrillation
Using the Delphi method of arriving at a consensus among clinicians concerning for which patients with atrial fibrillation should oral anticoagulants be recommended, the risk of stroke, the risk of hemorrhage, and patient-specific factors emerged. Many of these factors are not included in the guidelines and should be studied further.
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Treating Depression in Epilepsy: To Medicate or Not?
Epileptic patients with major depression were randomized to either cognitive behavioral therapy (CBT) or sertraline. Depression and related secondary health outcomes were analyzed in both groups. Sertraline and CBT were found to be equally efficacious with improvement in mood in more than half of patients.