Internal Medicine Alert
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Amyloid, Tau, Neurodegeneration Diagnostic Framework to Predict Memory Decline Before the Onset of Dementia
In a population-based longitudinal study of older individuals without dementia, the inclusion of imaging biomarkers for amyloid, tau, and neurodegeneration modestly improved the ability to predict memory decline compared to a model that only used clinical data and APOE genotype.
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Blood Pressure Targets in the Elderly
The authors of a large population study found that reducing blood pressure to < 140/90 mmHg is associated with increased mortality, and mortality was highest in those with previous cardiovascular events and age > 80 years.
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Vaping and Severe Acute Pneumonitis
Hundreds of cases of lung injury possibly related to vaping have been reported to the CDC. Evidence to date suggests the illness is a form of acute lipoid pneumonia likely related to inhalation of lipid materials.
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What Might Account for the ST-T Changes?
The ECG in the figure was obtained from a 65-year-old woman who presented with an exacerbation of heart failure. A medical history revealed she was taking multiple medications. The patient was dyspneic and complained about intermittent chest pain.
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Pitolisant Tablets (Wakix)
Pitolisant should be prescribed to treat excessive daytime sleepiness in adult patients with narcolepsy.
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When Did You Last Take an Antibiotic?
Approximately half of U.S. residents with health insurance filled an antibiotic prescription over a two-year period.
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Risk of Neuropathy With Fluoroquinolones
As a class, fluoroquinolones are some of the most commonly used antibiotics worldwide. Their use carries a significant risk of neurotoxicity, for both the peripheral and central nervous system.
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Neuropathy After Total Knee Arthroplasty
In a large series of cases from the Mayo Clinic, 54 cases of new neuropathy occurred in 14,450 total knee arthroplasties. Most were isolated peroneal neuropathies. No specific risk factors were identified.
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NOACs vs. Warfarin: What Are the Data in Patients With Traumatic Brain Injury and Intracranial Hemorrhage?
A three-year analysis of a prospectively maintained database with traumatic brain injury patients revealed that novel oral anticoagulant use is associated with increased risk of intracranial hemorrhage progression, neurosurgical intervention, and mortality.
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Darolutamide Tablets (Nubeqa)
Darolutamide should be prescribed to patients with nonmetastatic, castration-resistant prostate cancer.