Internal Medicine Alert
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Can One Be Certain About the Rhythm Diagnosis?
The 12-lead ECG and long lead II rhythm strip in the figure was obtained from a patient who was hemodynamically stable. What is the rhythm in the figure? Why can one be virtually certain what the rhythm diagnosis is before attempting a vagal maneuver or using medication?
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Ubrogepant Tablets (Ubrelvy)
Ubrogepant is indicated for the acute treatment of migraine with or without aura in adults.
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Prognosis in Small Fiber Neuropathy
Small fiber neuropathy is a common disorder that causes chronic pain, but rarely progresses to disability or more severe neurological disorders. Management of the pain continues to be the major treatment challenge.
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Colonization With Clostridioides difficile Frequently Leads to a Misdiagnosis of Healthcare-Associated Infection
A prospective cohort study from a single institution revealed 27% of patients diagnosed with healthcare-associated Clostridioides difficile infection were colonized with the same isolate on admission.
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Does Exercise Decrease Incident Depression in a High-Risk Population?
The authors of this large-scale, observational study found that three or more hours weekly of physical activity was associated with a decreased incidence of depression, even in patients with a high genetic risk of depression.
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Lemborexant Tablets (Dayvigo)
Lemborexant should be prescribed to treat adults with insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
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Stable Coronary Disease and Atrial Fibrillation Patients Best Treated With Rivaroxaban Alone
Monotherapy with rivaroxaban was noninferior to combination therapy for the primary efficacy endpoint of composite of stroke, systemic embolism, myocardial infarction, unstable angina, or death from any cause.
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What Is the Optimal Blood Pressure for Secondary Prevention of Stroke?
Investigators terminated a study early before they could draw any firm conclusions. Thus, there remains a lack of solid evidence to support a firm recommendation regarding optimal blood pressure management for secondary stroke prevention.
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Dapagliflozin Treatment Improves Life Quality for Systolic Heart Failure Patients
Treatment with dapagliflozin for 12 weeks resulted in improved health status, either a reduction in NT-proBNP or improvement in quality of life measures, in systolic heart failure patients with or without type 2 diabetes mellitus.
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Menopausal Hormonal Therapy and Breast Cancer Risk: Are Old Data Relevant to Today’s Practice?
An individual-participant meta-analysis of prospective studies revealed menopausal hormone therapy associated with an elevation in the risk of breast cancer, with the highest risks associated with daily combined therapy.