Internal Medicine Alert
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Ozanimod Capsules (Zeposia)
Ozanimod should be prescribed to treat relapsing multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
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Cannabis for Mental Health Disorders: Follow the Evidence
In a review of 83 eligible studies, researchers found little evidence to support the efficacy of cannabinoids to treat depressive disorders, anxiety disorders, or several other mental health disorders.
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The Cascade Effect: Calcium Channel Blockers and High Blood Pressure
Many older adults who are prescribed calcium channel blockers subsequently receive a loop diuretic. Awareness of this common cascade may reduce unnecessary prescribing and potential harm.
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More Mediterranean Diet Benefits: Diverse Microbiomes, Better Health Among Seniors
A randomized, multicenter study showed that eating a Mediterranean diet for one year improved the diversity of the gut microbiome in older subjects and was associated with reduced frailty and better health.
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Osilodrostat Tablets (Isturisa)
Osilodrostat should be prescribed to adult patients with Cushing's disease for whom pituitary surgery is not an option or has not been curative.
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Cannabis in the Treatment of Headache and Migraine
The authors of this observational study found nearly a 50% reduction in self-reported headache and migraine severity following use of inhaled medicinal cannabis.
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Warfarin or DOACs for Atrial Fibrillation in Chronic Kidney Disease?
A large outpatient observational study of patients with atrial fibrillation and chronic kidney disease who were anticoagulated revealed that, compared to warfarin, direct oral anticoagulants exhibited less all-cause mortality and major bleeding with at least equivalent efficacy at preventing stroke.
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Anatomic vs. Functional Testing in Older Coronary Artery Disease Patients
An analysis of the PROMISE trial by age showed cardiovascular death or myocardial infarction was predicted by a positive stress test in patients with symptoms suggesting myocardial ischemia who were > age 65 years.
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Pharmacotherapy Considerations for COVID-19
A summary of selected pharmacotherapy options proposed to treat COVID-19.
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This ECG Was in Your ‘Pile to be Read’
Imagine the ECG in the figure was one of many tracings you received to read from a group of patients seen by other providers in your clinic. Unfortunately, no clinical information about this patient was available. How would one interpret this tracing? Considering no clinical information regarding what happened to the patient was available, what is the next step?