Internal Medicine Alert
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Decitabine and Cedazuridine Tablets (Inqovi)
Inqovi should be prescribed to treat adults with myelodysplastic syndromes.
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Cheyne-Stokes Respiration in Heart Failure
A comprehensive cardiorespiratory study of stable systolic heart failure patients showed Cheyne-Stokes breathing in the awake, upright position is related to hypercapnia and is independently associated with a higher risk of cardiac death.
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Risks of Hookah Smoking
An average hookah contains as much tobacco as 20 filtered cigarettes. The nicotine hit from a hookah is every bit as real and as addictive as smoking cigarettes. The temperature of the smoke when heated electronically in newer hookahs, rather than by older charcoal versions, may be cidal to lung cells.
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High Lateral Infarction, or Something Else?
The ECG in the figure was obtained from a man with new onset palpitations. What is the probable cause of his symptoms? Is there high lateral infarction, or is something else accounting for the Q waves in leads I and aVL?
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Inappropriately Broad Empiric Antibiotics, Higher Mortality, and Community-Onset Sepsis
A retrospective cohort study revealed broad-spectrum antibiotics were unnecessarily prescribed to patients with community-onset sepsis and were associated with worse outcomes and higher mortality.
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Insulin Lispro-aabc Injection (Lyumjev)
Lyumjev is indicated to improve glycemic control in adults with diabetes mellitus.
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Clostridioides difficile: Risk Factors for Disease
Approximately one-tenth of asymptomatic patients with Clostridioides difficile colonization went on to develop disease. A wide range of antibiotic exposures represent a significant risk.
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Benefits of Exercise in Established Atrial Fibrillation
A large, long-term, prospective, Norwegian population study of patients with established atrial fibrillation revealed physical activity at or above recommended levels reduces all-cause and cardiovascular mortality vs. atrial fibrillation patients who are inactive.
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Group Beating from Wenckebach?
The two rhythm strips in the figure were recorded just a few minutes apart. There is group beating. Is the rhythm the result of atrioventricular (AV) Wenckebach (second degree AV block, Mobitz Type I)?
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Elagolix, Estradiol, and Norethindrone Acetate Capsules (Oriahnn)
Elagolix-EN should be prescribed to manage heavy menstrual bleeding associated with uterine leiomyomas (fibroids) in premenopausal women.