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Delaying Antibiotics in Patients with Suspected Infection Increases Risk of Septic Shock

A retrospective cohort study revealed delaying the first dose of antibiotics in patients suspected of presenting with an infection in the ED led to a higher risk of progressing to septic shock and in-hospital mortality. Every hour antibiotics were delayed raised the risk of septic shock by 4%.

How Certain is a Negative Echocardiogram for Excluding Infective Endocarditis?

Applying the proposed strict negative criteria for infective endocarditis (IE) on the first echocardiogram indicated this approach largely prevented unnecessary repeat tests unless clinically indicated for continued suspicion of IE.

Finding the Most Effective Treatment for Hair Loss in Men

Among three common treatments for male androgenic alopecia, the authors of a meta-analysis found 0.5 mg/day of dutasteride to be the most effective.

VIRSTA vs. PREDICT: Which Is Best for Anticipating Endocarditis?

Researchers in Columbia put predictive scoring methods through their paces.

Adverse Effects of Electronic Cigarettes on the Disease-Naïve Oral Microbiome

A robust metagenomic comparison study of the effects of electronic cigarettes on oral microbiomes suggested that the unique aerosol component of electronic cigarettes poses increased risk to development of oral cavity disease.

Post-Exercise Premature Ventricular Contraction, or Aberrancy?

The ECG in the figure is a post-exercise tracing. There are four wider and slightly early occurring beats in the long lead rhythm strips. Are these beats premature ventricular contractions or premature atrial contractions conducted with aberration?

Incidence, Prevalence, and Long-Term Consequences of Small Fiber Neuropathy

Small fiber neuropathy (SFN) associated with diabetes and other causes is more likely to progress to large-fiber polyneuropathy, deteriorate faster, and cause worse disability vs. slow progression with idiopathic SFN.

Coronary CT Angiography in the General Population

Coronary artery CT angiography in asymptomatic, middle-aged subjects without known coronary artery disease showed coronary atherosclerosis is common but mostly mild and appears in women after a 10-year delay.