Internal Medicine Alert
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Deucravacitinib Tablets (Sotyktu)
Deucravacitinib can be prescribed to adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
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Increasing Incidence of Stage IV Cervical Cancer
The incidence of stage IV cervical cancer in the United States between 2001 and 2018 increased. Rates were highest among Black women, but the annual rate of increase was highest among white women in the South age 40-44 years.
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Vitamin D3, Omega-3 Supplements for Older Adults to Lower Frailty Risk
Data from a large, randomized trial that included 25,871 adults age 50 years or older indicated 2,000 daily units of vitamin D3 and 1 g daily of omega-3 fatty acid supplementation did not affect frailty.
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Importance of Medication Adherence in Ischemic Heart Disease
The results of a subanalysis of the ISCHEMIA trial indicated about one-quarter of patients in both conservative and invasive strategy groups were nonadherent to recommended medical therapy at baseline. Nonadherence was associated with worse health status in both groups at baseline and after one year.
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Evidence of Clinical Efficacy of Bebtelovimab in COVID-19
In a retrospective study, bebtelovimab demonstrated efficacy similar to Paxlovid in high-risk outpatients with recent onset of COVID-19 who reported mild to moderate symptoms.
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Spironolactone May Help Treat Chronic Alcoholism
Both animal and human studies suggest spironolactone might be a new agent for helping patients with alcohol use disorder cut their intake.
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Sodium Phenylbutyrate and Taurursodiol for Oral Suspension (Relyvrio)
Relyvrio can be prescribed to treat amyotrophic lateral sclerosis in adults.
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The Dental Procedure-Infective Endocarditis Link Controversy Continues
Infective endocarditis was more common with dental surgery or tooth extractions in the preceding four weeks in high-risk patients. Researchers abrogated this risk with antibiotic prophylaxis before the procedure.
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Long-Term Outcomes in Intracerebral, Intraventricular Hemorrhage
It is important to avoid giving a poor prognosis early in the clinical course, and to continue supportive care until the long-term outcome truly is understood.
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Benefits, Risks of Dual Antiplatelet Therapy After Acute Ischemic Stroke or TIA
It will be important to determine the actual frequency of the CYP2C19 loss-of-function gene. Clinicians should consider point-of-care testing for patients before selecting and initiating dual antiplatelet therapy.