Internal Medicine Alert
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A Patient with Pneumonia
The ECG in the figure was obtained from an elderly man who was admitted to the hospital with pneumonia. This ECG was obtained after his admission when he began to complain of chest pain. There are two important findings on this patient’s ECG. Can you identify them?
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Low-Fat vs. Mediterranean Diet for Secondary Prevention
A study of stable coronary heart disease patients comparing the Mediterranean diet to a low-fat diet over a seven-year follow-up showed the Mediterranean diet was superior at preventing major cardiovascular events.
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Is It Better to Up-Titrate Medications Faster in Acute Heart Failure Patients?
Early intensive up-titration of guideline-recommended therapy in patients admitted for heart failure reduced 180-day readmission and all-cause mortality rates at the cost of more adverse events (but not serious or fatal ones).
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New Therapy for Resistant Hypertension
Aprocitentan demonstrated efficacy for additional therapy beyond standard multidrug treatment in resistant hypertension.
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Current and Future Options for Male Contraception
The following is a summary of the existing male contraceptive options and an overview of future ones.
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Tocilizumab Injection (Actemra)
The FDA has approved tocilizumab injection to treat COVID-19 among hospitalized adult patients who are receiving systemic corticosteroids and require supplemental oxygen.
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Body Weight Decline in Cognitively Intact Older Adults May Predict Future Cognitive Impairment
Among cognitively intact individuals, those who developed mild cognitive impairment (MCI) recorded faster body mass index (BMI) decline and significantly lower BMI seven years before MCI diagnosis.
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Is Red Meat Really Unhealthy?
A thorough review of the evidence raises questions about the health risks of eating unprocessed red meat.
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Triglyceride-Lowering Therapy and Cardiovascular Events
Researchers studied pemafibrate vs. placebo in patients with type 2 diabetes, mild-to-moderate triglyceride elevations, and low levels of HDL and well-controlled LDL cholesterol. Despite a 31% reduction in triglyceride levels, there was no improvement in the risk of cardiovascular outcomes over a median follow-up of 3.4 years.
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COVID-19: Beware Remdesivir Resistance
Researchers reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in RNA-dependent RNA polymerase after remdesivir treatment.