Internal Medicine Alert
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Ablation vs. Drug Therapy for Atrial Fibrillation, Revisited
A three-year follow-up of EARLY-AF, a study of relatively young and healthy patients with recent atrial fibrillation, showed cryoablation remains superior to drug therapy for preventing the development of persistent atrial fibrillation.
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Magnetic Brain Stimulation for Alzheimer’s Disease
Transcranial magnetic stimulation, targeted at the precuneus to help maintain a normal default mode network, shows some promise in slowing cognitive decline and maintaining normal electrophysiology in patients with mild to moderate Alzheimer’s disease.
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Do Spinal Cord Stimulators Really Help for Chronic Pain?
The results of a comprehensive analysis of a large clinical database regarding treatment of patients with chronic low back pain did not support the benefit of spinal cord stimulators compared to conventional medical management for chronic pain.
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Bexagliflozin Tablets (Brenzavvy)
Bexagliflozin can be prescribed as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
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Long-Term Air Pollution Exposure Could Raise Risk for Depression, Anxiety
Two research groups reported on breathing dirty air and how that affects mental health.
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For Older Americans, More Steps Lead to Better Cardiovascular Health
In a meta-analysis, researchers found walking 6,000 to 9,000 steps daily lowered the risk of cardiovascular disease by 40% to 50% vs. walking 2,000 steps daily.
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Chlorthalidone vs. Hydrochlorothiazide: Which Is Superior for Treating Hypertension?
Randomly switching half of patients with hypertension on hydrochlorothiazide to chlorthalidone did not produce any difference in major cardiovascular outcomes.
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Resistance of SARS-CoV-2 Variants to Monoclonal Antibodies
Prevalent SARS-CoV-2 variants are persistently resistant to therapeutic and prophylactic monoclonal antibodies but remain susceptible to nirmatrelvir/ritonavir, remdesivir, and molnupiravir.
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Vaccination Against Mpox: Does It Work? Is It Safe?
Vaccination, either subcutaneously or intradermally, with the non-replicating Jynneos monkeypox vaccine is safe and effective.
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Lecanemab-irmb Injection (Leqembi)
Lecanemab can be prescribed to treat Alzheimer's disease. Initiate this treatment in patients with mild cognitive impairment or mild dementia stage of disease, with confirmation of amyloid beta pathology.