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Daily vitamin E and multivitamin-mineral supplementation and acute RTI in elderly persons; B-Type natriuretic peptide levels and outcome in patients with heart failure; influence of companions during primary care medical encounters
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This cohort study prospectively compared the rate of change in the amount of coronary calcification before and after lipid-lowering therapy with the cholesterol synthesis enzyme inhibitor cerivastatin.
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There appears to be an increase in ovarian cancer with long-term estrogen-only hormone replacement therapy.
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Ambulatory blood pressure monitoring is a useful adjunct for evaluating white coat hypertension, but little is known about its effect on BP. Thus, Hermida and associates from Spain studied 538 patients with mild-to-moderate office hypertension using ABPM for 48 hours.
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There is evidence that diet could play a role in Alzheimer's disease (AD) risk. This epidemiologic study examined the risk of AD between quartiles of calorie, carbohydrate, fat, and protein intake after adjusting for confounders.
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In patients with heart failure and diabetes, metformin is not associated with harm and may reduce all cause mortality.
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The FDA has approved a new drug for the treatment of advanced breast cancer.
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Asymptomatic brain MRI findings of infarct, cerebral aneurysms and benign tumors were fairly common in the general population. The clinical significance of these findings is unknown.
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Two hundred eighty-eight patients hospitalized with severe community-acquired pneumonia (CAP) were followed for 28 days in a prospective multicenter study. At day 7, 25% of patients had resolution of CXR abnormalities and 56% had improvement. At day 28, 53% of patients had resolution of CXR abnormalities and 78% had clinical cure. By multivariate analysis, delayed resolution of CXR abnormalities by day 7 was associated with multilobar disease, dullness to percussion by physical exam, elevated CRP (> 200 mg/L), and tachypnea (respiratory rate > 25/min.) on admission.
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A randomized controlled trial in Australia showed that a 16 week program of tai chi reduced falls by 33% in a group of elderly persons.
