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Internal Medicine Alert

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Articles

  • The Holy Grail of Diagnosing Depression: An Effective Blood Test

    An objective, laboratory based diagnostic tool for depression would be extremely helpful to primary care physicians. This study using nine biomarkers holds promise that a blood test may be able to identify depressed patients among non-depressed primary care patients
  • ECG Review: What’s Going On?

    The 12-lead ECG and accompanying rhythm strip in the Figure were obtained from an 84-year-old man who presented to the Emergency Department with acute dyspnea from pneumonia and heart failure. Whats going on?
  • Clinical Briefs

    Efficacy of Handrubbing with Alcohol-Based Solution vs. Standard Handwashing with Antiseptic Soap: Randomized Clinical Trial; A Program To Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home; Treatment of Chronic Painful Diabetic Neuropathy with Isosorbide Dinitrate Spray
  • Melatonin for Jet Lag

    This study assessed the effectiveness of oral melatonin taken in different dosage regimens for alleviating jet-lag after air travel across several time zones.
  • Pharmacology Watch: High-Dose Rofecoxib Confirmed Prothrombotic, Study Shows

    Debate over the cardiovascular effects of COX-2 inhibitors has raged for more than a year since a special communication was published in JAMA last August suggesting an increase in cardiovascular events with rofecoxib (Vioxx). Now a large retrospect, the cohort study from the Tennessee Medicaid program seems to confirm the prothrombotic effects of rofecoxib, at least in high dose.
  • Pharmacology Update: Dutasteride Capsules (Avodart — GlaxoSmithKline)

    GlaxoSmithKline is expected to launch a new drug for benign prostatic hypertrophy in December. Dutasteride is a 5 alpha-reductase inhibitor, which was previously approved in November 2001 but not launched.
  • Don’t Turn Your Head and Cough: It’s a Woman Thing

    Among patients being evaluated for chronic cough, women are more sensitive than men to inhalation of tussive agents.
  • For Better or Worse

    Expanding upon their earlier study that demonstrated that spouses of hypertensive patients are more likely to be hypertensive themselves, these British researchers studied couples to determine whether other illnesses exhibited the same association.
  • Increased Caloric Intake Increases the Risk of Alzheimer’s Disease

    There is evidence that diet could play a role in Alzheimer's disease (AD) risk. This epidemiologic study examined the risk of AD between quartiles of calorie, carbohydrate, fat, and protein intake after adjusting for confounders.
  • The Ambulatory BP Monitoring Effect

    Ambulatory blood pressure monitoring is a useful adjunct for evaluating white coat hypertension, but little is known about its effect on BP. Thus, Hermida and associates from Spain studied 538 patients with mild-to-moderate office hypertension using ABPM for 48 hours.