Internal Medicine Alert
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Fecal Microbiota Transplantation: Patients Need No Convincing
Fecal microbiota transplantation appears effective in approximately 55-90% of patients with relapsing and refractory Clostridium difficile infection, and will prove a blessing to those who have been in a miserable cycle of recurrent disease.
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Optimal Beta-blocker Dose Post-MI
Investigators from the Outcome of Beta-blocker Therapy After Myocardial Infarction (OBTAIN) study hypothesized that the higher the dose of beta-blocker the lower the mortality.
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Metformin and Colorectal Cancer Risk
In a retrospective cohort study of patients with type 2 diabetes who had ≥ 1 adenoma detected at baseline colonoscopy and a repeat colonoscopy 1-10 years later, metformin use lowered the risk of subsequent adenomas after polypectomy.
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Cardiovascular Events Associated with Masked Hypertension and White-coat Hypertension
Analysis from the Dallas Heart Study consisting of 3027 adults revealed that both white-coat hypertension and masked hypertension were independently associated with increased cardiovascular events, and, therefore, home blood pressure monitoring is recommended for U.S. adults, whether symptomatic or asymptomatic.
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ECG Review: Early Repolarization or Something More?
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Clinical Briefs
In this section: potential good cardiovascular news; spironolactone best add-on for resistant hypertension; and questions about Vitamin D for primary care practice.
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Mepolizumab Injection (Nucala)
Mepolizumab is indicated for add-on maintenance treatment of adult patients ≥ 12 years of age with severe asthma and with an eosinophilic phenotype.
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Carotid Occlusion Rarely Develops from Asymptomatic Carotid Artery Stenosis
Recent study indicates that the risk of progression to carotid occlusion is well below the risk of carotid stenting or carotid endarterectomy.
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Utility of Non-traditional Risk Factors in Patients Ineligible for Statin Therapy
Adding additional risk factors not in the pooled risk equation to low-risk subjects identified a sub-group with an observed event rate > 7.5% who may warrant statin therapy.
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Effect of Modified Valsalva Maneuver for Emergency Treatment of Supraventricular Tachycardia
In patients presenting with supraventricular tachycardia, a modified Valsalva maneuver with leg elevation and supine positioning at the end of strain was demonstrated to be more effective than the standard Valsalva maneuver at restoring normal sinus rhythm.