Internal Medicine
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Sofpironium Topical Gel (Sofdra)
The U.S. Food and Drug Administration has approved a second topical anticholinergic product for the treatment of hyperhidrosis.
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Enlargement of Choroid Plexus in Subacute COVID-19 Patients
The choroid plexus is a network of capillaries whose main role involves facilitating cerebrospinal fluid production and the exchange of nutrients and waste products between the central nervous system and the bloodstream. Immune cells are present near the choroid plexus. Enlargement of the choroid plexus has been noted in patients with multiple sclerosis.
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Chlorthalidone vs. Hydrochlorothiazide for Hypertension
A subgroup analysis of those with prior myocardial infarction or ischemic stroke in the Diuretic Comparison Project for the treatment of hypertension has found that this higher-risk group experiences fewer major adverse cardiovascular events while taking chlorthalidone compared to hydrochlorothiazide, but at the expense of more hypokalemia.
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TB Screening Dismayingly Low in Those at Risk
Screening for latent tuberculosis (TB) infection in persons at risk is woefully lax in our country — and yet, reactivation TB is such an eminently preventable disease.
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Is It Past Time to Change Dietary Guidelines for Alcohol Use?
Analysis reveals that previous studies demonstrating the health benefits of moderate alcohol drinking were of low quality and that the relatively few published studies meeting the minimal quality criteria to avoid this problem do not show significantly lower mortality risk for moderate alcohol drinkers.
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The Cath was “Clean!”
The featured electrocardiogram was obtained following successful resuscitation from cardiac arrest. Although echo done soon after showed akinesis of the anterior wall, no significant coronary narrowing was seen on cardiac catheterization. Can you explain? What is this phenomenon called?
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Donanemab-azbt (Kisunla)
The U.S. Food and Drug Administration has approved the third anti-amyloid beta monoclonal antibody for the treatment of Alzheimer’s disease, following aducanumab and lecanemab.
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Dengue Is Surging, Including in the Americas
Dengue is surging, and cases have been acquired in the United States, including in Puerto Rico and Florida.
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CVD Risk from Ketogenic Diets
A recent analysis of the UK Biobank data found that subjects on a low-carbohydrate, high-fat diet had higher levels of low-density lipoprotein cholesterol and apolipoprotein B, and an increase in incident major adverse cardiovascular events over a 12-year follow-up than subjects on a standard diet.
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Comparing Antidepressants’ Effects on Weight Gain
This observational study finds that, compared to sertraline, six-month weight gain is higher in patients prescribed other antidepressants in the same category (paroxetine, citalopram, escitalopram) as well as in patients prescribed duloxetine and venlafaxine, similar in patients prescribed fluoxetine, and lower in patients prescribed bupropion.