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Osteoarthritis (OA) can be described as the failed repair of damage that has been caused by excessive mechanical stress (defined as force/unit area) on joint tissues.1 This implies that although multiple factors may lead to OA, mechanical impact (either as a major single event or as repetitive micro trauma) is central to all of these, and that the sequence of events that ensues represents the intrinsic repair process, which may either fail or be successful in restoring joint function. Also known as osteoarthrosis or degenerative joint disease, OA is the most important chronic musculoskeletal disorder in both humans and horses.
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The updated practice guidelines for the treatment of atrial fibrillation include information on the newer treatments for rhythm control, treatment options to reduce atrial fibrillation complications, and updated anticoagulant management for thromboprophylaxis.
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Long-term Mortality Among Adults with Asthma; Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes; New Hope for Hepatitis C Patients
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A new serotonin and norepinephrine reuptake inhibitor (SNRI) has been approved by the FDA for the treatment of major depressive disorder (MDD).
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In a large, international observational study, patients who had repair of flail mitral valve leaflets within 3 months of diagnosis had better long-term survival and a lower risk of heart failure than those managed with watchful waiting.
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Beta-blockers and noncardiac surgery; prenatal medication exposure and risk of autism; reasons for statin discontinuations; and FDA actions.