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Resistance to antibiotics continues to pose a serious problem in treating infections. While new pharmaceutical agents are being developed, interest in alternative treatments is also growing. Grapefruit seed extract is one commercially available antimicrobial that has attracted considerable attention.
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In this issue: Clopidogrel and proton pump inhibitors; adverse events with tamsulosin after cataract surgery; new guidelines for persistent pain in the elderly; and FDA Actions.
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Although breast cancer may not be the most common cancer in women, the diagnosis or even the suspicion is a cause of great distress. Primary care physicians play a pivotal role in their female patients' care by providing the proper risk assessment, encouraging women to get the regular screening, and providing patients with the appropriate referral to definitive treatment.
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A variety of highly effective agents for primary insomnia are currently available including benzodiazepines, benzodiazepine receptor agonists, and other classes. Agents that impact the benzodiazepine receptors (i.e., either benzodiazepines or benzodiazepine receptor agonists) are controlled substances and have occasional problematic issues such as misuse, diversion, cognitive clouding, and rebound upon withdrawal.
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In elderly patients hospitalized with heart failure and LVSD, beta-blocker use was clinically effective in reducing mortality and rehospitalization, but patients with preserved systolic function had poor outcomes and beta-blockers did not significantly influence the mortality and rehospitalization rate for these patients.
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Iloperidone is the newest atypical antipsychotic agent to be approved by the FDA. It is chemically similar to risperidone and ziprasidone. Vanda Pharmaceuticals will market iloperidone as Fanaptâ„¢.
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In patients with proximal deep vein thrombosis (DVT), tailoring the duration of oral anticoagulation based on serial ultrasonography reduces the rate of recurrent DVT. Prolongation of chronic anticoagulation may accelerate vein recanalization. Residual DVT on ultrasonography is a marker of hypercoagulability.