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Autologous CD4+ T-cells modified to delete CCR5 by Zinc-finger nuclease (ZFN) were infused into 12 HIV-infected patients. Cells survived in the circulation of patients and provided some control of viral replication and immune reconstitution after interruption of antiretroviral therapy.
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TB rates among pre-school aged children in the United States are 32 times higher in foreign-born children and six times higher in U.S.-born children with at least one foreign-born parent, compared to U.S.-born children with U.S.-born parents.
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Hepatitis C virus (HCV) infection is an important global health issue that affects approximately 184 million people. Conventional therapy for HCV with interferon and ribavirin is associated with high rates of virological failure and severe side-effects.
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As many as 10% may be non-responders
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The use of dabigatran in patients with mechanical heart valves compared with patients receiving warfarin was associated with increased rates of thromboembolic and bleeding complications, thus demonstrating no benefit and an excess risk.
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In a study of men in the Veterans Affairs health care system with low serum testosterone levels, the use of testosterone therapy was associated with an increased risk of mortality, myocardial infarction, or ischemic stroke.
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Historically, men with high-risk prostate cancer were believed to have low survival rates after definitive treatment with either surgery or radiation. However, long-term results of dose-escalated radiotherapy of doses ≥ 75.6 Gy, along with long-term androgen deprivation therapy (ADT), demonstrate 5-year survival rate of 92%, 5-year biochemical control rate of 82%, and symptomatic local failure rate of 0%. Death from prostate cancer was only 5.5% at 10 years in men treated with high-dose radiation therapy and ADT.
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