Infectious Disease
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High Lateral Infarction, or Something Else?
The ECG in the figure was obtained from a man with new onset palpitations. What is the probable cause of his symptoms? Is there high lateral infarction, or is something else accounting for the Q waves in leads I and aVL?
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Fostemsavir Extended-Release Tablets (Rukobia)
Fostemsavir is indicated, with other antiretrovirals, to treat HIV-1 infections in heavily treatment-experienced adults with multidrug-resistant HIV-1 infections who are failing current regimens.
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COVID-19 and Steroids: Is There a Consensus?
A study of adults admitted with COVID-19 pneumonia revealed risk factors associated with developing acute respiratory distress syndrome (ARDS) and progression from ARDS to death included older age, neutrophilia, organ dysfunction, and coagulation derangement.
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Inappropriately Broad Empiric Antibiotics, Higher Mortality, and Community-Onset Sepsis
A retrospective cohort study revealed broad-spectrum antibiotics were unnecessarily prescribed to patients with community-onset sepsis and were associated with worse outcomes and higher mortality.
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Thin Evidence Supporting the Obesity Paradox in STEMI
This largest-to-date analysis of six randomized studies of ST-elevation myocardial infarction revealed no association between body mass index and infarct size, one-year mortality, or heart failure hospitalization.
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Study: No Relationship Between Blood Type, COVID-19 Severity
But those with certain blood types may be at higher risk for testing positive.
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Infectious Disease Alert Updates
Metronidazole Neurotoxicity Is Real; 2020 Updated LTBI Treatment Guidelines; Risks of Hookah Smoking
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A New Treatment for Recurrent Bacterial Vaginosis?
In this randomized controlled trial of 228 women, Lactobacillus crispatus CTV-05 (Lactin-V) applied vaginally for 11 weeks reduced the incidence of recurrent bacterial vaginosis from 45% in the placebo arm to 30% in the Lactin-V arm.
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Immunomodulatory Treatment of Disseminated Coccidioidomycosis
A previously healthy 4-year-old boy with no prior serious illnesses was diagnosed with disseminated coccidioidomycosis with prominent skin and bone involvement. Despite treatment with liposomal amphotericin B, antifungal azoles, and surgical debridement, the patient developed progressive disease. Treatment with interferon-gamma slowed disease progression, and later treatment with interleukin-4 and interleukin-13 blockade induced remission of his infection.
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Rotavirus Vaccine Is Safe and Effective
Routine rotavirus vaccination of infants, when implemented broadly, is safe and is associated with reductions in diarrhea-related hospitalizations, mortality, and morbidity (such as malnutrition) in children.