Infectious Disease
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A Novel Rifabutin-Containing Combination Regimen Eradicates H. pylori Infection
Researchers found a significantly higher eradication rate for H. pylori with a 14-day regimen of rifabutin, amoxicillin, and omeprazole compared to 14 days of amoxicillin and omeprazole.
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Race Correction in Clinical Calculations: Is It Time to Reconsider?
Many clinical calculators use race as a predictive variable to assess risk for outcomes. Although most tools assume a genetic disposition for these outcomes, other factors, such as health disparities and other potential confounders, are more likely to be the underlying reasons for any race-related differences in outcomes.
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More Is Not Better with Vitamin D Supplementation
A recent study revealed vitamin D levels higher than normal from high-dose supplementation are harmful to bone health.
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Is There Right Ventricular Strain or Acute Pulmonary Embolism?
The ECG in the figure was obtained from a middle-age woman who presented with new dyspnea. Is the T wave inversion in the inferior leads a reflection of right ventricular “strain” from acute pulmonary embolism? If not, what else might cause these ECG findings?
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COVID-19 Vaccine Update
There are dozens of vaccine candidates undergoing investigation in human and animal trials. Only a few have reached Phase III testing. This is a closer look at those.
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Gut Microbiome in Patients at Risk for Parkinson’s Disease
Certain risk factors and prodromal markers of Parkinson’s disease (PD), such as constipation and rapid eye movement sleep behavior disorder, are associated with specific bacterial compositions of the gut. However, the value of gut microbiome data to predict the risk of PD development needs further investigation.
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Auditory Startle Response as a Predictor of Recovery from Coma
Preserved habituation of the auditory startle response, performed bedside, indicates intact cortical structures and cortico-cortical white matter tract connections. Preservation of this reaction in patients with unresponsive wakefulness can help distinguish the vegetative state from minimally conscious state and may even predict eventual awakening.
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Oral Calcitonin Gene-Related Peptide Antagonist for Migraine Prevention
Atogepant, an oral calcitonin gene-related peptide antagonist, was shown to be effective and safe for migraine prevention.
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Antibiotic Use in COVID-19 Patients
Fifty-seven percent of patients with COVID-19 infection treated at 38 hospitals in Michigan received early empiric antibiotics, although researchers documented community-onset bacterial coinfection in only 3.5%.
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HHS Releases Latest Iteration of Antibiotic Resistance Action Plan
The five-point strategy crafted in previous years remains the same, but the tactics have improved to help execute the goals. The new plan includes details about stronger and more evidence-based activities that have reduced antibiotic resistance that public health officials can lean on to drive progress.