Infectious Disease
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Does the Addition of IV Metronidazole Improve Outcomes of Severe Clostridioides difficile Infection?
These studies indicate that the addition of intravenously administered metronidazole in the treatment of severe Clostridioides difficile infection is unwarranted.
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With Focus on COVID-19, Other HAIs Increase
Infection preventionists are reporting increasing outbreaks of healthcare associated infections as the COVID-19 pandemic demands outsized efforts by overworked caregivers.
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Malaria and Anemia — Chemoprophylaxis Helps
For young children in Africa who return home after hospitalization for severe anemia, monthly long-acting malaria prophylaxis can reduce the rates of readmission and death during the three months following hospitalization.
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Candidemia in the United States
Candidemia, a common bloodstream infection in the United States, is associated with high mortality. There is concern about increasing resistance to antifungals.
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COVID-19 Shots Causing Anaphylactic Shock at 10 Times Rate of Other Vaccines
With millions more healthcare workers and the general public slated to be immunized for COVID-19, researchers report that the Pfizer SARS-CoV-2 mRNA vaccine is causing anaphylactic shock reactions at 10 times the rate of typical vaccines.
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Healthcare Workers with Antibody to SARS-CoV-2 Have Strong Protection Against Reinfection
A study of healthcare workers demonstrated that the presence of antibody to SARS-CoV-2 spike protein or to nucleocapsid provides strong protection against infection with this virus for up to six months.
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CDC: At Least 50% of COVID-19 Spread by Asymptomatic Cases
The United States has had about 23 million cases of COVID-19 as of Jan. 13, 2021. According to the Centers for Disease Control and Prevention, at least 11.5 million of those cases were transmitted by someone without symptoms.
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Early Convalescent Plasma for Treatment of COVID-19 in Elderly Patients with Mild Symptoms
Administration of convalescent plasma obtained from survivors of COVID-19 within 72 hours of onset of mild symptoms in elderly patients with COVID-19 was associated with a significant reduction in the risk of development of severe respiratory disease.
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SARS-CoV-2 Antibodies and Multisystem Inflammatory Syndrome in Children
SARS-CoV-2-related multisystem inflammatory syndrome in children (MIS-C) can be severe and life-threatening. New data suggest that the degree of elevation of spike protein receptor-binding domain antibodies could serve as a diagnostic marker of MIS-C as well as point to potential pathogenic processes.
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Emerging Coronavirus Variants Narrow the Margin for Error
A highly transmissible variant of the SARS-CoV-2 virus originally from the United Kingdom is emerging rapidly in the United States, with 76 cases detected in 12 states when this report was filed.