Infectious Disease
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Viloxazine Extended-Release Capsules (Qelbree)
Viloxazine should be prescribed to treat ADHD in patients age 6 to 17 years.
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Exercise Intervention for Improving Metabolic-Associated Fatty Liver Disease
Researchers assessed the histological appearance of liver biopsies from patients with metabolic-associated fatty liver disease (MAFLD) who completed 12 weeks of structured and supported aerobic exercise. Compared to biopsies from a nonexercising control group, the intervention arm demonstrated some reversal of histopathologic changes caused by MAFLD.
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Intracranial Plaque Rupture and Stroke
An MRI study of cerebral circulation in patients with embolic stroke of undetermined etiology showed evidence of atherosclerotic plaque in most patients.
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Ketogenic Diet Improves Cognition, Daily Function in Alzheimer’s Disease Patients
In a randomized, crossover trial, patients with Alzheimer’s disease on a ketogenic diet for 12 weeks demonstrated improved cognition, daily function, and quality of life.
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Infectious Disease Alert Updates
Aussie Flesh-Eating Disease; Misleading Imaging in COVID; Abstruse 2021 CLABSI Case Definition
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Ebola — Sometimes it Does Not Go Away
A patient without apparent immunodeficiency experienced a late relapse of Ebola virus disease with subsequent transmission causing 91 secondary cases. Such late relapse raises concerns regarding control of this disease.
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Candida Endocarditis
A review of a national administrative database examined 703 patients with Candida endocarditis and found the greatest risk factor for mortality was underlying liver failure, while a history of opiate abuse was associated with a reduced risk of death.
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Antibiotic Therapy: How Long Is Long Enough (or too Long)?
The Centers for Disease Control and Prevention and the American College of Physicians have provided advice on the best practice regarding the duration of antibiotic therapy for a number of common infections.
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Reduced Incidence of Kawasaki Disease During the Time of COVID-19
Mitigation in response to COVID-19 has been associated with decreases in common childhood respiratory infections. The incidence of Kawasaki disease from April to December 2020 was significantly decreased from the same period during the previous eight years.
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Response to COVID-19 Vaccination in Solid Organ Transplant Recipients
The apparent immunogenicity of available SARS-CoV-2 messenger ribonucleic acid vaccines is markedly reduced in solid organ transplant recipients, providing concern that they may not provide protection from symptomatic COVID-19 in many.