Infectious Disease
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Treatment of Invasive Aspergillosis in Solid Organ Transplant Recipients: Isavuconazole or Voriconazole?
An analysis of two retrospective cohort studies of solid organ transplant recipients with invasive aspergillosis found that isavuconazole and voriconazole had similar efficacy, but isavuconazole was better tolerated.
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Vitamin D Supplementation to Prevent Respiratory Infections?
In June 2024, the Endocrine Society released new evidence-based guidelines suggesting that all children up to 18 years of age should receive vitamin D supplements, both to prevent rickets and to prevent respiratory tract infections. However, careful review of the data suggests that widespread implementation of this recommendation might not be warranted in North America.
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Trichinella Outbreak from Eating Bear Meat and Cross-Contaminated Vegetables
A family outbreak of trichinellosis occurred after a feast of bear meat and vegetable kabobs that was caused by a species of Trichinella that is resistant to freezing.
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Newer Antibiotics for Resistant Gram-Negative Infections: Why Are Clinicians Not Using Them?
A retrospective cohort study on adult inpatients with difficult-to-treat resistant pathogens found clinicians used older, generic antibiotics with suboptimal safety profiles in almost 80% of cases.
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Infectious Disease Alert Updates
Nontyphoidal Salmonella Drug Resistance in the United States; Alternative to Fecal Microbiota Transplant; How Best to Save that Prosthetic Joint
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‘Vampire’ Facials and HIV Transmission
Evidence indicates that human immunodeficiency virus was transmitted in association with microneedling of facial lesions with platelet-rich plasma.
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Respiratory Syncytial Virus or Influenza in Older Patients: Which Is Worse?
In individuals 75 years of age or older, respiratory syncytial virus infection was associated with more severe illness than was influenza virus infection.
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Do Bed Nets Prevent Cancer?
When used properly, bed nets prevent malaria in endemic areas. A new systematic review and a meta-analysis confirm that bed net use also is associated with a reduced incidence of Burkitt lymphoma in children in sub-Saharan Africa.
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New (Old) Treatment for Scabies
With increasing concern about reduced effectiveness of topical 5% permethrin cream against scabies, new data show that topical therapy with 25% benzyl benzoate is significantly more effective than permethrin.
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De-Escalation of an Empiric Antipseudomonal Beta-Lactam Is Appropriate with Enterobacterales Bacteremia
Patients with Enterobacterales bacteremia were assigned randomly to receive a course of an anti-pseudomonas beta-lactam or de-escalation to a narrower agent based on sensitivity results. De-escalation was non-inferior to continuing empiric therapy.