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Intravascular, device-related bloodstream infection (IDR-BSI) are a major source of morbidity and mortality. An estimated 250,000 infections occur annually in the United States, with an attributable mortality of 12-25%.
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Staphylococcus epidermidis continues to be a troublesome pathogen, mainly due to its ability to form biofilms that protect this species and allow it to express unique features that guarantee its survival. The main molecules involved in biofilm formation are under intense study.
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Mykietiuk and colleagues report that 139 (7.2%) of 1934 prospectively evaluated adults without severe immunocompromise admitted over an approximately 8-year period to a university hospital in Barcelona because of community-acquired pneumonia (CAP) had evidence of Legionella infection.
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This study emphasizes the need for increased awareness and monitoring for the potential development of excessive suppression of bone turnover during long-term alendronate therapy.
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The first of a new class of antidiabetic drugs has been approved for the treatment of type 2 diabetes mellitus.
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Increased intake of folate in any form is associated with a reduced risk of developing hypertension for women.
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Esomeprazole 20 mg and 40 mg daily improve upper GI symptoms occurring during NSAID therapy, including selective COX-2 inhibitors.
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Management of asthma in America remains problematic, with as many as 5,000 deaths annually in recent years.
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The FDA has approved a new intravenous antifungal agent.