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Previous studies have suggested that aseptic loosing of joint prostheses may be caused by infection with non culturable bacteria. This study found that PCR testing of operative specimens for bacterial 16s RNA did not identify the presence of bacteria if adequate microbiologic processing of specimens was performed and was negative.
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In this small, retrospective analysis, surgical drainage of epidural abscesses was not associated with improved outcomes, even in patients who presented with neurological deficits.
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Statins lower the levels of c-reactive protein (CRP) as well as the levels of LDL cholesterol (LDL-C). Whether lowering the CRP affects the clinical outcomes of statin therapy has not previously been investigated.
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Although chronic oral antiarrhythmic prophylaxis and catheter ablation both enjoy great success for preventing recurrences of atrial fibrillation (AF), some patients are not appropriate candidates for either method, especially patients with infrequent recurrences of AF.
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Examining data from a 20-year time period, correlations were sought between antisecretory drug therapy and cumulative incidence of dysplasia. Incidence of dysplasia was significantly lower in patients who had received proton pump inhibitor therapy vs no therapy or H2-receptor antagonists.
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Increased hospitalizations for abnormal bleeding were found in new users of selective serotonin reuptake inhibitor (SSRI) antidepressants, with more risk associated with SSRIs containing greater degrees of serotonin reuptake inhibition.
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The most commonly prescribed statins have a low incidence of rhabdomyolysis, according to the results a new study of more than 250,000 patients.
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A new nonbenzodiazepine hypnotic has been approved by the FDA for the treatment of insomnia.
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Pravastatin is the statin with the least interactions with cytochrome P450-(CYP) 3A4 inhibitors.