Infectious Disease
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Resistance Erodes Standard Treatment for Pneumonia
These data suggest community-acquired pneumonia CAP therapy may no longer be relevant for many patients with CAP, and the required use of the current CAP bundle with limited antibacterial therapy choices should be re-assessed.
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Pediatric Tuberculosis
Mycobacterium tuberculosis (MTB) is a significant challenge to children's health. Barriers exist at multiple levels of the care system for MTB. Early recognition and involvement of MTB specialists is critical to facilitate the best outcome for pediatric patients. The authors provide a thorough review of the current standards for care of these challenging patients.
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Overdiagnosis of Chronic Kidney Disease in the Elderly
Older patients experience a physiological decline in estimated glomerular filtration rate. However, if the same levels are used to define chronic kidney disease for all adults, older patients not at a higher risk for kidney failure might still be classified with the disease.
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Regulators Sign Off on COVID-19 Vaccine ‘Mix and Match’
Federal agencies expand, clarify guidance on booster shots.
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What Is the ‘Bix Rule?’
The ECG in the figure was obtained from a middle-aged man with a history of exertional chest pain and dyspnea. How would one interpret this tracing? Does the red arrow in lead II show a sinus P wave?
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Atogepant Tablets (Qulipta)
Atogepant can be prescribed to prevent episodic migraine in adults.
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Progression of Coronary Calcium on Statin Treatment
In those treated with statins vs. those who were not, statins decreased plaque volume in plaques with little or no calcium (plaque regression) and increased calcium density without changes in plaque volume in calcified plaques (plaque stabilization).
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Adjuvanted Zoster Vaccine: Persistent Protection
The adjuvanted recombinant zoster vaccine efficacy is high and persistent, with apparent plateauing at > 84% four to six years after vaccination.
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First-Line Therapy for Hypertension
When comparing angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARBs) to treat hypertension, researchers observed no difference in major cardiovascular events — but a better safety profile for ARBs.
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Carbohydrates and Insulin Resistance: Pondering Food Quality vs. Quantity
Researchers posit that solving the obesity epidemic is not as simple as eating less and moving more.