Infectious Disease
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Fluvoxamine Reduces the Risk for Hospitalization from COVID-19
A randomized, placebo-controlled trial found fluvoxamine (100 mg twice a day for 10 days) reduced the risk for hospitalization among high-risk outpatients diagnosed with COVID-19.
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Melioidosis in the United States
Four cases of melioidosis in four states occurred and at least one was traced to a contaminated commercial aromatherapy product.
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Pediatric Pneumonia — Diagnostic and Therapeutic Stewardship
A randomized, multicentered trial in the United Kingdom and Ireland showed children receiving amoxicillin for community-acquired pneumonia perform similarly well with lower dose (35-50 mg/kg/day vs. 75-90 mg/kg/day) and shorter duration (three vs. seven days) treatments.
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Surviving Sepsis 2021 Update
Some of the important changes include clearer differentiation of sepsis vs. septic shock and, for numerous recommendations, changing the strength and quality of evidence to support many.
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Positive STI Test Results Not Always Shared with Study Participants
Investigators should develop a plan to return test results to participants, and document their actions in protocols and manuscripts. IRBs should require researchers to include these details in their proposals.
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Moral Distress When Caring for Patients on Mechanical Circulatory Support
Clinicians pointed to palliative care and ethics consults as ways to mitigate moral distress.
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Celecoxib and Tramadol Hydrochloride Tablets (Seglentis) C-IV
Seglentis can be prescribed to adults to help them manage acute pain that is severe enough to require an opioid analgesic.
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Surgical Approaches to Decompression in Degenerative Lumbar Spondylolisthesis
For patients with symptomatic lumbar stenosis and single-level spondylolisthesis who were refractory to conservative treatment, there was no significant difference between outcomes in those who underwent decompression surgery with instrumented fusion vs. decompression surgery without fusion.
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Homelessness and COVID-19
Extra screening in care for homeless persons can help solve many problems, including the administration of COVID-19 vaccination to this vulnerable population.
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Slow, Steady, and Synchronized Wins the Race
In patients with atrial fibrillation and heart failure, definitive rate control via atrioventricular junction ablation and biventricular pacing resulted in a significant reduction in all-cause mortality vs. pharmacologic rate control.