Infectious Disease
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Treatment of Severe Plasmodium falciparum Malaria with Intravenous Artesunate
A prospective nationwide study in France found intravenous artesunate use was rapidly adopted by clinicians and was safe and highly effective in the treatment of severe malaria due to Plasmodium falciparum.
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Leapfrog Patient Safety Group Pushing for Lower HAI Rates
The Leapfrog Group, a patient safety watchdog organization, is redoubling efforts to prevent healthcare-associated infections and other adverse events that have increased during the pandemic as it examines data and results from its policy suggestions.
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Malaria in the United States
The number of cases of imported malaria in the United States continues to increase, with most cases caused by Plasmodium falciparum and most of the infections acquired in Africa, particularly West Africa. Almost three-fourths of U.S. residents with malaria had failed to take chemoprophylaxis and the remaining one-fourth often did not take recommended medications.
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Malassezia restricta as a Cause of Culture-Negative Infective Endocarditis
The authors of a retrospective study from France used DNA detection methods to assess the microbial etiologies of 16 cases of culture-negative infective endocarditis. They identified three cases of Malassezia restricta, a yeast considered a member of the human skin microbiota. Notably, serologic testing cross-reacted between M. restricta and Candida albicans.
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Mumps in Vaccinated Children
Recent mumps outbreaks in the United States have involved vaccinated individuals without international travel. The genotype of the mumps virus circulating in North America and Europe is different than that of the virus used to manufacture the attenuated vaccine used in the United States.
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Infectious Complications Carry Ethical Implications for End-of-Life Care
Many assume antibiotics are a simple solution to infectious complications, which is not always the case. Clinicians must explain the downstream effects of traumatic injuries and ICU care to families in detail so they can see how each bump in the road will affect the patient.
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Pilocarpine Hydrochloride Ophthalmic Solution 1.25% (Vuity)
Pilocarpine ophthalmic solution (OS) can be prescribed to treat presbyopia.
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Intensive Monitoring for Asymptomatic Atrial Fibrillation Did Not Prevent Strokes
Screening with an implantable loop recorder resulted in dramatically higher rates of atrial fibrillation detection and ensuing anticoagulation, but without a significant decrease in risk of stroke or systemic embolism by six years of follow-up.
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Importance of Age in the Application of Coronary Artery Calcium Detection
Using coronary CT strategy as a diagnostic first line in patients with symptoms suggestive of coronary artery obstruction revealed relying on the coronary calcium score alone is inadequate for younger patients with a higher frequency of non-calcified obstructions.
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Reduce the Risk of Autoimmune Disease with Vitamin D, n-3 Fatty Acid Supplements
A randomized, controlled trial that included older adults showed vitamin D3 2,000 units daily or n-3 fatty acids 1,000 mg daily over five years reduced the incidence of autoimmune diseases 25% to 30%.