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Neuropsychiatric side effects and sleep disturbances are among the more prominent and limiting features of efavirenz (EFV) therapy for HIV infection.
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In order to reduce the rate of catheter-related bloodstream infections (CRBSIs) in intensive care units, Northwestern Memorial Hospital implemented patient care bundles in all ICUs in August 2005.
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HOPS is an ongoing prospective, observational cohort study of HIV-infected patients at 10 participating HIV clinics in the United States. A total of 2,699 patients with HIV RNA > 1,000 copies/uL were seen from 1999-2005. Demographic characteristics, clinical factors, and GPT use were correlated with all-cause mortality.
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In this issue: Tamoxifen and CYP2D6 inhibitors, FDA Actions, and FDA
Warnings.
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In January 2009, the publication of an updated vancomycin monitoring guideline1 gave clinicians a set of recommendations on: 1) timing of monitoring, 2) optimal trough concentration, 3) dosing to achieve optimal trough concentrations, 4) loading doses for complicated infections, 5) criteria for monitoring, and 6) frequency of monitoring.
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The case is typical. the patient had a hip replacement eight years ago and, over the past six months, the hip has begun to hurt, walking is impaired, and the patient is becoming less mobile. The hip must be replaced. But is it infected?
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A prospective study of congenital cytomegalovirus (CMV) infection was conducted in two hospitals in São Paulo, Brazil, from 2003 to 2007 in a maternal population with high seroprevalence to CMV.
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Patients eligible for EFV-based haart (EFV plus two nucleoside RT inhibitors) were randomized to EFV in an escalating dose over two weeks vs. standard 600 mg/d dosing. NPAEs and sleep quality were assessed by questionnaires over the first 30 days of therapy.