Infectious Disease
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Initial Antibiotic Choice for Neonatal Sepsis in Low- and Middle-Income Countries
Gram-negative rods are responsible for most neonatal sepsis in low- and middle-income countries. Ampicillin-gentamicin usually has been recommended for presumptive treatment, pending bacteriology results (when such tests are available). The results of a multinational study in Africa and Asia suggest resistance to standard therapy is widespread and that ceftazidime-amikacin might be a better option.
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Third Documented HIV Remission Case Emerges
Woman with acute myeloid leukemia underwent stem cell transplant, which apparently sent the virus into remission.
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Urgent Need for ‘Universal’ Vaccines for SARS-CoV-2
There is an emerging consensus in the scientific community that is two-fold: COVID-19 is not going away anytime soon, and continuous vaccine boosters eventually could yield diminishing returns. What is needed are new, second-generation vaccines that confer broader immunity against both circulating variants and mutations yet to arise.
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APIC Sets New Strategic Priorities Amid COVID-19
Like other healthcare workers, infection preventionists have been overwhelmed in the churning waves of the SARS-CoV-2 pandemic. An unpublished survey conducted by the Association for Professionals in Infection Control and Epidemiology and The Ohio State University School of Nursing revealed a “startling” level of stress and burnout.
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Omicron ‘Milder’ Infection View Skewed by Prior Immunity
The COVID-19 omicron variant has been widely observed to cause “milder” disease, but this appears largely to be an illusion caused by the level of immunity via prior infection or vaccination that now exists in the human population.
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Infectious Disease Experts Sound Alarm on True Toll of RSV
Respiratory syncytial virus (RSV) is something of a contradiction: The leading cause of hospitalization of infants in the United States (58,000 annually) is largely unappreciated beyond the pediatric population. In what essentially is a hidden seasonal epidemic, RSV causes 177,000 hospitalizations and 14,000 deaths annually in the United States in those age 65 years and older.
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Clindamycin Vaginal Gel 2% (Xaciato)
Clindamycin gel can be prescribed to treat bacterial vaginosis in women age 12 years and older.
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Screen Older Heart Failure Patients for Transthyretin Cardiac Amyloidosis
A screening study of heart failure patients ≥ age 60 years, left ventricular ejection fraction ≥ 40%, and left ventricle wall thickness ≥ 12 mm revealed 6.3% prevalence of transthyretin cardiac amyloidosis, a highly treatable disease.
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Is Physical Activity Associated with Mortality Risk in Parkinson’s Disease?
In individuals with Parkinson’s disease (PD), physical activity (PA) at all intensities was associated with lower all-cause mortality rates, with the greatest reduction seen in individuals who maintained PA before and after PD diagnosis.
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Multiple Sclerosis and Immune Response to COVID-19 Vaccination
A large group of patients with multiple sclerosis taking various disease-modifying therapies did not respond uniformly to COVID-19 vaccination.