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Vaccination has dramatically reduced the number of cases of chickenpox, measles, polio, mumps, and pertussis treated in primary care settings. Antibiotic treatment of streptococcal pharyngitis has reduced the number of cases of rheumatic fever. As a result, there are generations of physicians who have never encountered patients with these diseases. These diseases are often relegated to the historical section of general medical textbooks. However, recent isolated outbreaks in adults as well as children have brought these diseases back into the forefront for primary care providers.
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The authors conclude that this large observational study suggests ACEI or ARB therapy is associated with an improved survival and a lower risk of cardiovascular events in patients with aortic stenosis.
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A kinase inhibitor for late-stage melanoma and its companion diagnostic test have been approved by the FDA.
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Both urgency and bladder pain can lead to nocturia in patients with interstitial cystitis.
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For many patients with moderate- severe chronic obstructive pulmonary disease, acute exacerbations (AECOPD) are highly problematic.
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In nonvalvular atrial fibrillation patients, rivaroxaban was noninferior to warfarin for the prevention of stroke or systemic embolism. However, an intention-to-treat analysis did not show superiority of rivaroxaban over warfarin.
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It has been well recognized that a peak in stroke onset occurs during the early morning hours. This possible circadian periodicity is not well understood, and may in part represent stroke onset earlier during the night that goes unrecognized until the patient arouses.
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Sickle cell disease celebrated its 100th anniversary last year, prompting consideration of what has transpired for those with the disease since its description by Dr. James Herrick in 1910.
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