Infectious Disease
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Marburg Virus Outbreak in Ghana — Should We Worry?
An outbreak of Marburg virus disease, an illness resembling Ebola, is occurring in Ghana, only the second such event in West Africa. Will it spread beyond Africa?
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Ibrexafungerp for Vulvovaginal Candidiasis
The authors of a randomized clinical trial compared one day of oral ibrexafungerp with placebo for women with vulvovaginal candidiasis (VVC). They found ibrexafungerp to be safe and effective, with mild diarrhea the most common adverse event. Ibrexafungerp differs mechanistically from azoles and appears to be a promising new treatment for VVC.
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Parechovirus Meningoencephalitis in Infants
Parechovirus A3 is a leading cause of meningoencephalitis in infants.
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Novavax COVID-19 Vaccine, Adjuvanted (NVX-CoV2373)
Novavax is authorized to be administered to patients age 18 years and older for active immunization to prevent COVID-19 caused by SARS-CoV-2.
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COVID-19 Rebound
Symptomatic and virologic recrudescence after treatment of patients with COVID-19 with Paxlovid occurs in a tiny percentage of patients and generally is mild and self-limited.
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COVID-19: Duration of Shedding of Transmissible Virus
Patients with COVID-19 were found, by culture, to shed replication-competent virus after an initial PCR test for median durations of four to five days.
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New Details Emerge About Acute Flaccid Myelitis, Cases Could Surge This Year
Researchers uncovered evidence indicating enterovirus D68 directly infects neurons in the spinal cord, prompting an immune response that leads to the limb weakness that is characteristic of acute flaccid myelitis. Investigators shed important light on the disease process that takes place in children who develop this polio-like illness. This is progress that can help lead to better treatments.
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Text Messages Boosted Pediatric Flu Vaccination Rates
Personalized, interactive, educational reminders led parents to bring children for the second shot faster and at a higher rate.
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Outcomes of COVID-19-Associated Acute Myocarditis
In a review of COVID-19-associated acute myocarditis, investigators learned it is a rare complication that can occur without concomitant pneumonia, and frequently presents as cardiogenic shock. With supportive therapy, the short-term mortality rate is low.
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EPA, FDA Partner on Safer Medical Device Sterilization
Agencies seek cuts to ethylene oxide emissions, safe alternatives.