Infectious Disease
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CDC, FDA sound alarm on recurrent problems in reprocessing
Warning that continuing infection control lapses are endangering patients, the CDC and the FDA recently issued a joint alert calling for healthcare facilities to review policies and practices in cleaning and processing reusable medical devices.
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Legionella Infections Surge and the CDC Revises its Guidance
Several issues are on the table, including the task of beginning outbreak investigations earlier based on a single confirmed infection.
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Clinical Briefs
In this issue: preventing recurrence of depression; predicting which patients with non-alcoholic fatty liver disease will progress; and treating premature ejaculation with tramadol.
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Cryptogenic Stroke and Atrial Fibrillation
Recent study results support monitoring patients > 60 years of age with evidence of prior stroke on brain imaging to look for atrial fibrillation.
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Alirocumab Injection (Praluent)
Alirocumab provides a new mechanism of action for lowering cholesterol in patients who have not achieved adequate lowering on maximum dose of statins.
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Migraine and Cognitive Dysfunction
During an attack of migraine without aura, patients may experience transient cognitive impairment, with predominant involvement of verbal processing speed, learning, and memory, due to reversible cortical dysfunction.
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Is Low Testosterone Therapy Worth the Hype in the Elderly?
Testosterone replacement therapy showed no impact on subclinical atherosclerosis progression in recent study.
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SGLT2 Inhibitors: Now The Bad News
Sodium-glucose cotransporter-2 inhibitors are approved as adjunctive therapy for the treatment of patients with type 2 diabetes. This drug class has been also used off-label to improve glycemic control in patients with type 1 diabetes.
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ECG Review: Is There Complete AV Block?
The simultaneously-recorded 3-lead rhythm strip in the figure was obtained from a 75-year-old woman who presented to the emergency department with syncope. She was diagnosed as being in complete (third-degree) AV block. Do you agree with this interpretation?
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Clinical Briefs
Treating symptomatic venous thromboembolism with warfarin; extending the window of anticoagulation after pulmonary embolus; and stroke accelerates long-term process of cognitive decline.