Infectious Disease
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Zika!
Zika virus infection has prompted international emergency responses due to its rapid spread in the Americas and its potential to alter brain development in pre-born children. Even as research progresses, prevention of infection depends on avoiding bites from Aedes mosquitoes.
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Clinical Briefs
In this section: another reason to take vitamin D supplements; polishing physical exam skills; and comparing the relationship between uric acid, fructose, and hypertension.
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Elbasvir and Grazoprevir Tablets (Zepatier)
The FDA has approved another oral interferon-free regimen for the treatment of chronic hepatitis C (HCV) genotypes 1 and 4.
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Should Postmenopausal Women Be Encouraged to Take Calcium?
A systematic review of randomized, controlled trials of calcium supplementation found only small non-progressive increases in bone mineral density. This supports the clinical conclusion that supplementation alone is insufficient to prevent fracture risk.
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Association of Coffee Consumption with Total and Cause-specific Mortality
Regular consumption of both caffeinated and decaffeinated coffee were found to be inversely associated with risk of total mortality and mortality attributed to cardiovascular disease and neurologic diseases.
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High Blood Pressure: How Low Should We Go? SPRINT and a New Meta-analysis
A recent meta-analysis supports the benefit of targeting lower blood pressure levels.
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ECG Review: What Has Happened in 8 Minutes?
The ECG in the figure illustrates how rapidly ST-T wave changes may develop during active stages of acute ST elevation myocardial infarction. In this case, no more than 8 minutes was necessary for the ECG to evolve from a minimally abnormal tracing to the dramatic picture of diffuse ST-T wave changes.
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Clinical Briefs
In this section: The measurement of C-reactive protein in hidradenitis patients may enhance assessment of disease severity; studying the relationship between gut flora and mood disorders; and weighing the benefits of administration of pre-exposure prophylaxis immediately before and after sexual activity.
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Lesinurad Tablets (Zurampic)
Lesinurad is a drug with a different mechanism of action to augment the action of a xanthine oxidase inhibitor, resulting in additional reduction of serum uric acid levels.
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Why Dentists Are Suddenly Smiling
In this meta-analysis of 51 randomized, controlled studies that included nearly 5000 patients, continuous positive airway pressure and oral appliances resulted in comparable and statistically significant reductions in blood pressure.