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2016 Was Not a Good Year for New FDA Anti-infectives

In 2016, two anti-hepatitis C virus combination drugs were approved, as were monoclonal antibodies directed at bacterial toxins (anthrax toxin and Clostridium difficile toxin B), as well as an oral cholera vaccine.

Treatment of Early Forms of Syphilis in HIV-Infected Patients

The results of this randomized trial provide support for the CDC recommendation of treatment of early stages of syphilis in HIV-infected patients with a single intramuscular 2.4-million-unit dose of benzathine penicillin.

A Potpourri of Global Viral Activity — It’s Always Something

Ross River virus, Sindbis virus, Kyasanur Forest disease, Lassa fever, avian influenza, MERS-CoV, and Seoul virus are among the viruses currently causing outbreaks.

Yellow Fever Redux

Yellow fever currently is epidemic in Brazil, and there is concern of further spread.

Antibiotic Use in Children — a Cross-national Analysis

Up to 7.5-fold differences in antibiotic use in children were seen across six developed countries in Europe, Asia, and North America. The highest rate of antibiotic use was in Korea, and the lowest was in Norway.

Antibiotic Use in Children — a Cross-national Analysis

Up to 7.5-fold differences in antibiotic use in children were seen across six developed countries in Europe, Asia, and North America. The highest rate of antibiotic use was in Korea, and the lowest was in Norway.

Clindamycin Improves Outcomes in Necrotizing Fasciitis Due to Group A Streptococcus

Using a murine model of necrotizing fasciitis, investigators determined that clindamycin inhibits key virulence factors of Group A Streptococcus, and should be given as soon as possible and at high doses to reach levels above MIC in affected tissues.

Vitamin D to Prevent Acute Respiratory Infections?

Vitamin D supplementation is associated with a decreased risk of respiratory infections, especially in those who had low circulating levels of 25-hydroxyvitamin D.