Infectious Disease
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Fludrocortisone for Orthostatic Hypotension Associated with Parkinson’s Disease
This double-center, double-blind, randomized, controlled trial compared the efficacy of pyridostigmine bromide vs. fludrocortisone and demonstrated that pyridostigmine bromide was not as effective as fludrocortisone.
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Risk Factors for Hospital Readmissions Ending in Death or Transition to Hospice
In this retrospective cohort study, multiple factors were identified during initial hospitalization, including sepsis and shock, that were associated with a hospital readmission within 30 days resulting in death or transition to hospice.
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Safe Treatment Recommendations for Benzodiazepine Dependence
There are clear, evidence-based treatment withdrawal regimens for benzodiazepine-dependent patients.
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Infectious Disease Alert Updates
Colistin Resistance in Action; PK-tailored High-dose Colistin May Not Be Beneficial; ‘Dragon’s Blood’ Yields Possible Antibacterial
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Oral Cholera Vaccine and Travelers
The new oral cholera vaccine is recommended for adults 18-64 years of age who are planning to travel to areas at risk.
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Surviving Sepsis Campaign Guidelines Bundle: Studying How Improved Compliance Might Affect Outcomes
Improved compliance with the Surviving Sepsis Campaign guidelines bundle was associated with a non-statistically significant decrease in the in-hospital mortality of severe sepsis patients.
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Ready for Dengue in the United States?
Dengue is increasingly recognized in the southern United States. When recently surveyed, however, clinicians in Texas seemed incompletely prepared to understand and manage patients with dengue.
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Bambi Strikes Again — Encephalitis Due to the ‘Deer Tick Virus’ (Powassan Virus) May Be Increasing in Frequency
Powassan virus is transmitted by the same tick that carries the etiologic agent of Lyme disease and several other pathogens. The number of cases of encephalitis caused by this virus may be increasing in the endemic areas.
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Current Trends and Outcomes for Infective Endocarditis
Using large databases from New York and California, investigators found the overall incidence of infective endocarditis remained stable between 1998 and 2013, and 90-day mortality declined. Changes were noted in pathogen etiology and patient characteristics over time.
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First Case of Hepatitis A Transmission by Transplant
Though hepatitis A virus (HAV) has spread via blood transfusion, the virus had never transmitted from a transplant patient. Now, through a circuitous chain of events, it has. Indeed, HAV spread from an organ donor to the transplant recipient, and then to three nurses providing post-transplant care, the CDC reports.1