Infectious Disease
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Valbenazine Capsules (Ingrezza)
Valbenazine is indicated for the treatment of tardive dyskinesia in adults.
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Insomnia Disorder: Evidence for Psychological and Behavioral Interventions
Cognitive behavioral therapy for insomnia is an effective intervention for moderate to severe insomnia disorder and should be considered as an initial treatment.
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Putting the Genie Back in the Prescription Bottle
Researchers recently developed an evidence-based algorithm for reducing the use of proton pump inhibitors.
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Infectious Disease Alert Updates
Antibiotic increases honeybee mortality; Sustained hepegivirus infection in injection drug users; Decrease SSIs: Take August off
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2016 Surviving Sepsis Guidelines Update
The Surviving Sepsis Campaign recently published an update to the 2012 guidelines for management of sepsis and septic shock. The document incorporates literature published through July 2016.
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Sepsis Management: What We Think We Know
In the Protocolized Resuscitation in Sepsis Meta-Analysis (PRISM), 3,723 patients’ outcomes from the ProCESS, ARISE, and ProMISe randomized, controlled trials of early goal-directed therapy (EGDT) were evaluated. EGDT did not result in better outcomes than usual care and was associated with higher costs. The authors of a second study looked at outcomes of 49,331 patients with sepsis treated in New York from April 2014 to June 2016. More rapid completion of the three-hour sepsis bundle and antibiotic administration (but not rapid bolus administration of IV fluids) was associated with reduced in-hospital mortality.
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Bug Bytes From Barcelona: Report of the 15th Conference of the International Society of Travel Medicine
In addition to issues of malaria, vaccination, and trauma in travelers, viral diseases and the management of diarrhea were key topics at the biannual meeting of the International Society of Travel Medicine in Barcelona, Spain, during May 2017.
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Not Just Ebola — Lassa Fever Rears its Ugly Head Once Again
Outbreaks of Lassa fever are occurring in Nigeria and several other West African nations, some of which also are endemic for Ebola virus infections.
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Dual Antibiotic Therapy Is Not Routinely Necessary for Uncomplicated Cellulitis
A randomized, multicenter, placebo-controlled clinical trial that enrolled patients presenting to emergency departments with uncomplicated cellulitis found the addition of trimethoprim-sulfamethoxazole to cephalexin did not lead to better outcomes.
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HCV: Is It Better to Test and Treat Than Try PEP?
Despite – or perhaps because of -- the incredible cure rates being achieved by new drugs for hepatitis C virus, experts say post-exposure prophylaxsis for exposed healthcare workers is not the path to pursue. Given a host of undermining variables, it is better to repeatedly test a worker who suffers a needlestick, ready to treat as soon as a seroconversion occurs, experts concur.