Infectious Disease
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Meropenem-vaborbactam
Meropenem-vaborbactam (Vabomere) is the latest β-lactam/β-lactamase inhibitor (BLI), approved by the FDA in August 2017 for treatment of complicated urinary tract infections (cUTI), including pyelonephritis, caused by susceptible Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae species complex in adults older than 18 years of age.
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Statin Use Is Associated With a Lower Risk of Community-acquired Staphylococcus aureus Bacteremia
A population-based case-control study from Denmark found the use of statins was associated with a decreased risk for community-associated Staphylococcus aureus bacteremia, with the greatest benefit from higher doses.
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Lyme Disease in the United States — Good News, Bad News
The incidence of Lyme disease appears to have stabilized in states with known high incidences of the infection, but there is evidence of geographic expansion into neighboring states.
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Mumps Vaccine — Third Dose During Outbreaks
Mumps immunity wanes over time, with a notable increase in risk of infection 13 or more years after completion of the currently recommended series of vaccines. During an outbreak of mumps, receipt of an extra (third, by American schedules) vaccine significantly reduces the risk of becoming sick with mumps.
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Fluticasone Furoate, Umeclidinium, and Vilanterol Inhalation Powder (Trelegy Ellipta)
Trelegy Ellipta is indicated for the long-term maintenance treatment of patients with COPD, including chronic bronchitis and/or emphysema.
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Clinical Briefs
In this section: Some good news for type 2 diabetes patients; hormone replacement during menopause; and chasing an unusual rosacea lead.
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Functional Outcomes After Receiving Life-sustaining Therapy in the ICU
Among patients who have spent at least three days in an ICU and required even brief mechanical ventilation and/or vasopressor support, almost half are dead and only one-third return to their baseline at six months. Several factors present on the first day of admission are associated with not returning to baseline status.
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Irritable Bowel Syndrome, Constipation, and Quality of Life in Women
Irritable bowel syndrome has a negative effect on women’s quality of life and affects one-third of women who present for care with fecal incontinence.
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Antibiotics and Adverse Events: Doctors, Do No Harm
A retrospective study found that among 1,488 hospitalized patients who received an antibiotic, 298 experienced at least one antibiotic-associated adverse drug event. Furthermore, 287 of the antibiotic regimens were not clinically indicated, and 56 of these were associated with an adverse drug event.
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Are Right-sided Leads Needed?
The ECG in the figure was obtained from a man in his 50s who presented with new severe chest pain. How would you interpret this tracing? What area(s) of the heart are involved? What is the likely culprit artery?