Infectious Disease
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Infectious Disease Alert Updates
Tuberculosis Transmission From NAAT-negative Patients; Worldwide Rabies Risk: Dogs; Patients Need to Rethink the ‘Quality’ in Healthcare
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Plazomicin (Zemdri)
Plazomicin is an aminoglycoside recently approved by the Food and Drug Administration for treating complicated urinary tract infections.
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Here Comes the Sun — And Here Comes Coccidioidomycosis
Another occupational outbreak of coccidioidomycosis in solar farm workers in an endemic area points to the continued risk and the difficulty of preventing such occurrences.
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In Patients Who Self-catheterize, Antibiotic Prophylaxis Prevents UTIs but Increases Antibiotic Resistance
A randomized, open-label, superiority trial found that daily antibiotic prophylaxis for patients who use clean, intermittent self-catheterization reduced symptomatic urinary tract infections by 48% over a 12-month period. Antibiotic resistance became prevalent in urinary isolates from the group receiving prophylaxis compared to controls.
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Childhood Diarrhea Varies Geographically Within Africa
Each year, 30 million preschool-aged children still get sick with diarrhea and 330,000 die. Most diarrheal illness and death is concentrated in a few high-risk areas, including parts of Benin, Lesotho, Mali, Nigeria, and Sierra Leone. Targeting preventive and therapeutic interventions in areas of risk could markedly reduce morbidity and mortality.
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Migalastat (Galafold) Capsules
Migalastat is indicated for the treatment of adults with confirmed diagnosis of Fabry disease and an amenable galactosidase alpha gene variant based on in vitro assay data.
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Poor Sleep Can Lead to Accelerated Atherosclerosis
New data provide further support for the importance of sleep in the optimization of medical outcomes.
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Coffee Consumption and Mortality
After rigorous evaluation using multiple statistics, an inverse relationship between coffee intake and all-cause mortality was demonstrated consistently across the racial/ethnic groups examined.
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Can Hormone Therapy Prevent the Development of a ‘Dowager’s Hump’?
Postmenopausal hormone therapy may reduce the risk of developing age-related hyperkyphosis, commonly known as a “Dowager’s hump.” Such therapy may provide long-term benefits.
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Carbohydrates, Insulin, and Obesity
Carbohydrate intake stimulates insulin secretion, which is the primary driver of weight gain. Besides driving glucose into cells, insulin causes fat storage, increases hunger, and lowers energy expenditure. High insulin blood levels lead to obesity with some genetic variation.