Infectious Disease
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Infectious Disease Alert Updates
Intestinal Yeast Revisited — With a New Angle; Preemptive Steroids for TB/HIV Treatment; Fluoroquinolone for Exposure to Drug-Resistant Tuberculosis
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Antimicrobial Susceptibility Testing in Cystic Fibrosis — An Unfortunate Failure
The results of antimicrobial susceptibility testing of respiratory isolates from patients with cystic fibrosis failed to predict outcomes of antibiotic therapy.
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Recurrent Clostridioides difficile Infection: Better Outcomes With Fecal Microbiota Transplantation Than With Antibiotics
Relative to vancomycin or metronidazole treatment of recurrent Clostridioides difficile infection, treatment with fecal microbiota transplantation is associated with a reduced risk of bloodstream infection, shorter hospital length of stay, and improved survival.
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Fatal Bacteremia Due to Fecal Microbiota Transplantation
Two patients developed bacteremia due to an extended-spectrum beta-lactamase producing Escherichia coli that had been transmitted to them via stool transplantation.
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Uninfected Children Exposed Prenatally to HIV Exhibit Language Delays
In South Africa, uninfected children exposed to human immunodeficiency virus (HIV) exhibit delays in receptive and expressive language at 24 months compared to non-HIV-exposed children.
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Colonization With Clostridioides difficile Frequently Leads to a Misdiagnosis of Healthcare-Associated Infection
A prospective cohort study from a single institution found 27% of patients diagnosed with healthcare-associated C. difficile infection were colonized with the same isolate on admission.
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Combination Therapy With Daptomycin Plus Beta-Lactam Antibiotics in MSSA Bacteremia
In a retrospective cohort study of 350 patients, the combination of a beta-lactam antibiotic plus daptomycin was not superior to beta-lactam monotherapy in patients with bacteremia due to methicillin-susceptible Staphylococcus aureus.
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Kill the Bug, Hurt the Worker
Powerful cleaning and disinfectant products are being deployed in hospitals to eradicate dangerous pathogens on environmental surfaces. Both spore-forming Clostridioides difficile and an emerging fungal strain of Candida auris require strong sporicidals to be eradicated from the hospital environment. Yet the price of protecting the patient is being exacted on healthcare workers who may have serious complications after repeated exposure to these chemicals in disinfectants.
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FDA Calls for Redesigned Scopes to Protect Patients
Conceding that conventional duodenoscopes cannot be reliably reprocessed between patients, the Food and Drug Administration is recommending that manufacturers and providers move to disposable components for the intricate devices.
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IPs Have Critical Role in Healthcare Worker Infection Guidelines
New guidelines by the Centers for Disease Control and Prevention to protect healthcare workers from infections call for infection preventionists to be key collaborators with occupational health departments.