Infectious Disease
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Airplane-Triggered Headaches
Severe, unilateral headaches that occur during airplane travel, particularly during landing, are most likely a variant of migraine headaches triggered by changes in cabin pressure.
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When to Administer the 13-Valent Pneumococcal Conjugate Vaccine: A Review of the ACIP Recommendations
Recently revised guidelines no longer recommend the 13-valent pneumococcal conjugate vaccine for most healthy adults.
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Infectious Disease Alert Updates
Objects of Delusional Infestation; Urine Eosinophils Unreliable; Tecovirimat for Laboratory-Acquired Vaccinia
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Omeprazole Magnesium, Amoxicillin, and Rifabutin Delayed-Release Capsules (Talicia)
The FDA has approved a fixed-dose combination, rifabutin-based (RFB) regimen to treat Helicobacter pylori infection.
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Markers and Mechanisms of Chronic Fatigue Following Mononucleosis
Chronic disabling fatigue affects up to 2% of adolescents and often follows Epstein-Barr virus-related mononucleosis. No clinically significant infectious, immune, neuroendocrine, or autonomic biomarker or pathophysiologic mechanism has been identified to differentiate those with mononucleosis who go on to develop chronic fatigue from those who recover.
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Cefazolin and Ertapenem as Salvage Therapy in Methicillin-Susceptible Staphylococcus aureus Bacteremia
Cefazolin (CZ) and ertapenem combination therapy was successfully used to salvage 11 cases of persistent methicillin-susceptible Staphylococcus aureus bacteremia. Modest in vitro synergy between CZ and ertapenem was demonstrated on testing of six clinical isolates, but in vivo activity appeared more potent in an animal model than as predicted by in vitro activity.
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Fulminant Clostridioides difficile Infection: Hold the IV Metronidazole?
The combination of oral vancomycin and intravenous metronidazole is not superior to vancomycin alone in the treatment of fulminant infection due to Clostridioides difficile.
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What Is the Risk of Joint Prosthesis Infection Resulting From Bacteremia?
The risk of periprosthetic joint infection resulting from bacteremia depends on the organism.
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Preventing Readmissions and Optimizing Outcomes for Staphylococcus aureus Bacteremia: Still a Long Journey Ahead
Using a population-based database, investigators found that the rate of readmission within 30 days following hospitalization for S. aureus bacteremia was high (22%) and resulted in high cost to the healthcare system.
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CDC: Fight Against AIDS at Key Inflection Point
CDC officials updated an ambitious plan to essentially end the AIDS epidemic in the United States in the next decade. While taking an overall national approach, the plan — part of a collaboration between the CDC and other federal agencies — would target specific geographic areas and at-risk populations.