Infectious Disease
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Cefiderocol Injection (Fetroja)
Cefiderocol should be prescribed to treat complicated urinary tract infections, including pyelonephritis, in adults ≥ 18 years of age with limited or no alternative treatment options.
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Vegetarians and Stroke
A recent study revealed vegetarians have a 22% lower incidence of ischemic heart disease, but a 20% increased incidence of total stroke, mostly related to hemorrhagic stroke, when compared to meat eaters.
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Clostridioides difficile Infection: Fecal Microbiota Transplantation vs. Antibiotics
Relative to vancomycin or metronidazole treatment of recurrent Clostridioides difficile infection, treatment with fecal microbiota transplantation is associated with a lower risk of bloodstream infection, shorter hospital length of stay, and improved survival.
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Dual Antiplatelet Therapy Increases Serious Hemorrhages Following TIA or Minor Stroke
Caution should be taken and close observation of patients maintained when treating with dual antiplatelet therapies.
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Soft Drinks and Death
Investigators found drinking more soft drinks, both artificially sweetened and sugar-sweetened, is associated with a higher risk of death, cardiovascular illness, and digestive illnesses.
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Airplane-Triggered Headaches
Severe, unilateral headaches that occur during airplane travel, particularly during landing, are most likely a variant of migraine headaches triggered by changes in cabin pressure.
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When to Administer the 13-Valent Pneumococcal Conjugate Vaccine: A Review of the ACIP Recommendations
Recently revised guidelines no longer recommend the 13-valent pneumococcal conjugate vaccine for most healthy adults.
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Infectious Disease Alert Updates
Objects of Delusional Infestation; Urine Eosinophils Unreliable; Tecovirimat for Laboratory-Acquired Vaccinia
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Omeprazole Magnesium, Amoxicillin, and Rifabutin Delayed-Release Capsules (Talicia)
The FDA has approved a fixed-dose combination, rifabutin-based (RFB) regimen to treat Helicobacter pylori infection.
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Markers and Mechanisms of Chronic Fatigue Following Mononucleosis
Chronic disabling fatigue affects up to 2% of adolescents and often follows Epstein-Barr virus-related mononucleosis. No clinically significant infectious, immune, neuroendocrine, or autonomic biomarker or pathophysiologic mechanism has been identified to differentiate those with mononucleosis who go on to develop chronic fatigue from those who recover.